-transparent.png){kind=logo}
Plasma immunoreactive motilin (IRM) concentrations were strikingly higher in patients with chronic renal failure (CRF) than in normal subjects. IRM in azotemic plasma was heterogeneous in gel-filtration profile. The first peak eluted in the void volume of the column and the second and the third one, comprising a major portion of IRM content, came out coincidentally with insulin and authentic motilin, respectively. By contrast, no discernible amount of IRM was found in the region corresponding with the second peak in gel-filtration of the plasma from normals and very little in a patient with ileus whole plasma IRM level was elevated. The hypermotilinemia and the accumulation of this high molecular weight motilin in patients with CRF suggest that the kidney plays some role in the elimination of motilin, and further, that the clearance of the high molecular motilin is more dependent on renal function than that of authentic motilin. The present paper emphasizes the necessity for clarifying the significance of the heterogeneity of IRM in CRF.
K Shima, and
S Shin, and
A Tanaka, and
E Hashimura, and
T Nishino, and
K Imagawa, and
Y Kumahara, and
N Yanaihara
January 1976,
The Journal of clinical endocrinology and metabolism,
K Shima, and
S Shin, and
A Tanaka, and
E Hashimura, and
T Nishino, and
K Imagawa, and
Y Kumahara, and
N Yanaihara
February 1996,
Zhonghua nei ke za zhi,
K Shima, and
S Shin, and
A Tanaka, and
E Hashimura, and
T Nishino, and
K Imagawa, and
Y Kumahara, and
N Yanaihara
September 1976,
The Journal of clinical investigation,
K Shima, and
S Shin, and
A Tanaka, and
E Hashimura, and
T Nishino, and
K Imagawa, and
Y Kumahara, and
N Yanaihara
August 1979,
Canadian Medical Association journal,
K Shima, and
S Shin, and
A Tanaka, and
E Hashimura, and
T Nishino, and
K Imagawa, and
Y Kumahara, and
N Yanaihara
March 1973,
Clinica chimica acta; international journal of clinical chemistry,
K Shima, and
S Shin, and
A Tanaka, and
E Hashimura, and
T Nishino, and
K Imagawa, and
Y Kumahara, and
N Yanaihara
January 1988,
Zeitschrift fur Kardiologie,
K Shima, and
S Shin, and
A Tanaka, and
E Hashimura, and
T Nishino, and
K Imagawa, and
Y Kumahara, and
N Yanaihara
January 1997,
International urology and nephrology,
K Shima, and
S Shin, and
A Tanaka, and
E Hashimura, and
T Nishino, and
K Imagawa, and
Y Kumahara, and
N Yanaihara
November 1975,
Journal of clinical pathology,
K Shima, and
S Shin, and
A Tanaka, and
E Hashimura, and
T Nishino, and
K Imagawa, and
Y Kumahara, and
N Yanaihara
April 1983,
Nihon Jinzo Gakkai shi,
K Shima, and
S Shin, and
A Tanaka, and
E Hashimura, and
T Nishino, and
K Imagawa, and
Y Kumahara, and
N Yanaihara
January 2002,
The hematology journal : the official journal of the European Haematology Association,
