Biomaterial Database

Focal nodular hyperplasia of the liver. An electron microscopic study of the vascular lesions. 1980

J Lough, and P Spicer, and R Kinch

Localized myointimal proliferation with narrowing of blood vessels is frequently seen associated with focal nodular hyperplasia of the liver. The apparent increase in the incidence of focal nodular hyperplasia in women may be associated with the oral use of contraceptive medications, and it has been suggested that the nodules could be areas of focal cirrhosis following liver infarction. A light and electron microscopic study was undertaken to try to determine the pathogenesis of the vascular abnormalities. The observation of intravascular coagulation, recurrent endothelial damage, and myointimal proliferation about bifurcations suggests that the changes could be produced by repeated platelet-fibrin aggregate embolic injury.

UI	MeSH Term	Description	Entries
D006965	Hyperplasia	An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.	Hyperplasias
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008854	Microscopy, Electron	Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.	Electron Microscopy
D002455	Cell Division	The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.	M Phase,Cell Division Phase,Cell Divisions,Division Phase, Cell,Division, Cell,Divisions, Cell,M Phases,Phase, Cell Division,Phase, M,Phases, M
D004727	Endothelium	A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body.	Endotheliums
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001158	Arteries	The vessels carrying blood away from the heart.	Artery