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Tests were done with various antibiotics (ampicillin, carbenicillin, cefazolin, cefotaxime, cephradine, ticarcillin) in order to determine the significance of sputum and pleural concentrations for adequate therapy of bronchopulmonary infections. In a total of 19 chronic bronchitis patients, it was found that the attainable sputum concentrations were rather low and that individual fluctuations were great. No clear connection was evident between dosage and concentration of antibiotics in the sputum. In 17 patients with exudative pleurisy, test data yielded in pleural kinetics largely corresponded with data from animal experiment models. The pleural cavity can be described as a partial extracellular, extravascular compartment in which the concentration course probably correlates more to the interstitial lung concentrations than to that of the sputum.
H Lode, and
G Gruhlke, and
W Hallermann, and
G Dzwillo
January 1985,
Schweizerische medizinische Wochenschrift,
H Lode, and
G Gruhlke, and
W Hallermann, and
G Dzwillo
January 1992,
Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna,
H Lode, and
G Gruhlke, and
W Hallermann, and
G Dzwillo
June 1973,
Hippokrates,
H Lode, and
G Gruhlke, and
W Hallermann, and
G Dzwillo
January 1982,
Revista de igiena, bacteriologie, virusologie, parazitologie, epidemiologie, pneumoftiziologie. Pneumoftiziologia,
H Lode, and
G Gruhlke, and
W Hallermann, and
G Dzwillo
January 1980,
Infection,
H Lode, and
G Gruhlke, and
W Hallermann, and
G Dzwillo
October 1950,
Deutsche medizinische Wochenschrift (1946),
H Lode, and
G Gruhlke, and
W Hallermann, and
G Dzwillo
January 1989,
Antibiotics and chemotherapy,
H Lode, and
G Gruhlke, and
W Hallermann, and
G Dzwillo
April 1972,
Deutsches medizinisches Journal,
H Lode, and
G Gruhlke, and
W Hallermann, and
G Dzwillo
January 1964,
Acta tuberculosea et pneumologica Scandinavica,
H Lode, and
G Gruhlke, and
W Hallermann, and
G Dzwillo
April 1982,
Infection and immunity,
