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Immediate electrocochleographic changes have been studied in a series of patients following intravenous infusion of either tobramycin or gentamicin. In patients receiving tobramycin, as soon as peak serum levels of antibiotic were reached, a dramatic decrease occurred in the magnitude of the compound VIII nerve action potential (AP), and of the cochlear microphonic (CM). The shape of the AP also changed. The N1 component of the waveform became very small, and N2 increased in size; this is the dissociated pattern of basal coil cochlear damage. The speed of onset of these electrical changes and their apparent reversibility suggests a temporary metabolic block caused by tobramycin. No such changes were observed following infusion of gentamicin.
R T Ramsden, and
P Wilson, and
W P Gibson
July 1998,
The Laryngoscope,
R T Ramsden, and
P Wilson, and
W P Gibson
April 1984,
Kidney international,
R T Ramsden, and
P Wilson, and
W P Gibson
December 1980,
The Journal of infectious diseases,
R T Ramsden, and
P Wilson, and
W P Gibson
March 1985,
Antimicrobial agents and chemotherapy,
R T Ramsden, and
P Wilson, and
W P Gibson
August 1976,
The Journal of infectious diseases,
R T Ramsden, and
P Wilson, and
W P Gibson
September 1982,
Anesthesia and analgesia,
R T Ramsden, and
P Wilson, and
W P Gibson
March 1974,
Lancet (London, England),
R T Ramsden, and
P Wilson, and
W P Gibson
January 1976,
Revue de laryngologie - otologie - rhinologie,
R T Ramsden, and
P Wilson, and
W P Gibson
February 1985,
Archives of ophthalmology (Chicago, Ill. : 1960),
R T Ramsden, and
P Wilson, and
W P Gibson
June 1986,
American journal of hospital pharmacy,
