Biomaterial Database

An interaction between dorsal and ventral regions of the marginal zone in early amphibian embryos. 1980

J M Slack, and D Forman

When small explants from early gastrulae of Xenopus laevis are allowed to develop in a buffered salt solution there is a considerable difference between the patterns of differentiation obtained from different dorsoventral levels of the marginal zone. These patterns of differentiation correspond to the fates of the different regions in the course of normal development. They are not altered if several explants of the same type are fused before culture. If a ventral marginal zone explant from Xenopus is cultured in contact with a piece of dorsal marginal zone from the axolotl, it forms structures more dorsal in character than it would in isolation or in normal development. This behaviour is shown only feebly with other regions of the axolotl gastrula. A piece of dorsal marginal zone from Xenopus is not affected in its development by culture in contact with an explant of ventral marginal zone from the axolotl. The dorsalization of ventral marginal zone explants is shown only if there is a large area of direct contact with the dorsal explant and if the pieces remain in contact for a period of 48 h or more. It is proposed that this in vitro interaction is the same as the dorsoventral component of action of the 'organizer' graft discovered by Spermann and Mangold.

UI	MeSH Term	Description	Entries
D002450	Cell Communication	Any of several ways in which living cells of an organism communicate with one another, whether by direct contact between cells or by means of chemical signals carried by neurotransmitter substances, hormones, and cyclic AMP.	Cell Interaction,Cell-to-Cell Interaction,Cell Communications,Cell Interactions,Cell to Cell Interaction,Cell-to-Cell Interactions,Communication, Cell,Communications, Cell,Interaction, Cell,Interaction, Cell-to-Cell,Interactions, Cell,Interactions, Cell-to-Cell
D002454	Cell Differentiation	Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.	Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D002478	Cells, Cultured	Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.	Cultured Cells,Cell, Cultured,Cultured Cell
D005775	Gastrula	The developmental stage that follows BLASTULA or BLASTOCYST. It is characterized by the morphogenetic cell movements including invagination, ingression, and involution. Gastrulation begins with the formation of the PRIMITIVE STREAK, and ends with the formation of three GERM LAYERS, the body plan of the mature organism.	Archenteron,Blastopore,Gastrocoele,Primitive Gut,Archenterons,Blastopores,Gastrocoeles,Gastrulas,Gut, Primitive,Guts, Primitive,Primitive Guts
D000557	Ambystoma	A genus of the Ambystomatidae family. The best known species are the axolotl AMBYSTOMA MEXICANUM and the closely related tiger salamander Ambystoma tigrinum. They may retain gills and remain aquatic without developing all of the adult characteristics. However, under proper changes in the environment they metamorphose.	Amblystoma,Ambystoma tigrinum,Tiger Salamander,Amblystomas,Ambystomas,Salamander, Tiger,Salamanders, Tiger,Tiger Salamanders
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D014981	Xenopus	An aquatic genus of the family, Pipidae, occurring in Africa and distinguished by having black horny claws on three inner hind toes.