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Serum and urine fibrin(ogen) degradation products (FDP), FDP clearances, and serum urea nitrogen (SUN) concentrations of rats challenged with glycerol-induced myohemoglobinuria were measured serially over a period of 4 days. The results obtained in animals that developed acute renal failure (ARF) were compared with those obtained in rats made refractory to renal failure by long-term salt loading or recent recovery from prior renal failure. Only the rats susceptible to ARF experienced a major rise in serum FDP concentration. Urine FDP excretion rose most markedly in the same rats but, being elevated in all groups. showed the utilization of fibrinogen whether serum FDP values increased or not. The results obtained might reflect differences in the degree of intravascular coagulation which are pathogenetically important. It is possible, however, that increased serum FDP concentrations found exclusively in rats with ARF are the results rather than the cause of impaired filtration, and that reduced tubular absorption may at least partly account for the high urinary FDP excretion observed in this model of experimental acute renal failure.
J S Carvalho, and
A C Carvalho, and
R A Vaillancourt, and
L B Page, and
R W Colman, and
D M Landwehr, and
D E Oken
January 1974,
Advances in nephrology from the Necker Hospital,
J S Carvalho, and
A C Carvalho, and
R A Vaillancourt, and
L B Page, and
R W Colman, and
D M Landwehr, and
D E Oken
June 1973,
Thrombosis et diathesis haemorrhagica,
J S Carvalho, and
A C Carvalho, and
R A Vaillancourt, and
L B Page, and
R W Colman, and
D M Landwehr, and
D E Oken
October 1971,
Thrombosis et diathesis haemorrhagica,
J S Carvalho, and
A C Carvalho, and
R A Vaillancourt, and
L B Page, and
R W Colman, and
D M Landwehr, and
D E Oken
March 1972,
British medical journal,
J S Carvalho, and
A C Carvalho, and
R A Vaillancourt, and
L B Page, and
R W Colman, and
D M Landwehr, and
D E Oken
January 1973,
Scandinavian journal of gastroenterology. Supplement,
J S Carvalho, and
A C Carvalho, and
R A Vaillancourt, and
L B Page, and
R W Colman, and
D M Landwehr, and
D E Oken
February 1974,
Gut,
J S Carvalho, and
A C Carvalho, and
R A Vaillancourt, and
L B Page, and
R W Colman, and
D M Landwehr, and
D E Oken
January 1989,
Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952),
J S Carvalho, and
A C Carvalho, and
R A Vaillancourt, and
L B Page, and
R W Colman, and
D M Landwehr, and
D E Oken
April 1973,
Archives of pathology,
J S Carvalho, and
A C Carvalho, and
R A Vaillancourt, and
L B Page, and
R W Colman, and
D M Landwehr, and
D E Oken
October 1974,
Annals of internal medicine,
J S Carvalho, and
A C Carvalho, and
R A Vaillancourt, and
L B Page, and
R W Colman, and
D M Landwehr, and
D E Oken
March 1989,
The American journal of physiology,
