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The effect of large doses (700 U/kg daily for 6 days) of heparin on the heart contractile function, myocardial morphology, content of free fatty acids in the blood, and the activity of tri- and monoglycerin lipase in blood plasma and heart tissue of intact rabbits was studied 24, 72 hours and 6 days after the beginning of heparin administration. It was established that the activity of lipolytic enzymes intensified, the concentration of free fatty acids in blood plasma grows, and the myocardial contractility increases after heparin administration. The phase structure of the cardiac cycle is simultaneously disturbed slightly. It is concluded that the intensification of lipolysis plays a role in increasing the myocardial contractility.
V A Frolov, and
E A Demurov, and
L V Efimova, and
T A Kazanskaia, and
V P Pukhlianko
February 1972,
Kardiologiia,
V A Frolov, and
E A Demurov, and
L V Efimova, and
T A Kazanskaia, and
V P Pukhlianko
August 1971,
Vrachebnoe delo,
V A Frolov, and
E A Demurov, and
L V Efimova, and
T A Kazanskaia, and
V P Pukhlianko
January 1979,
Farmatsevtychnyi zhurnal,
V A Frolov, and
E A Demurov, and
L V Efimova, and
T A Kazanskaia, and
V P Pukhlianko
January 1985,
Patologicheskaia fiziologiia i eksperimental'naia terapiia,
V A Frolov, and
E A Demurov, and
L V Efimova, and
T A Kazanskaia, and
V P Pukhlianko
February 1979,
Kardiologiia,
V A Frolov, and
E A Demurov, and
L V Efimova, and
T A Kazanskaia, and
V P Pukhlianko
January 1983,
Journal of cardiovascular pharmacology,
V A Frolov, and
E A Demurov, and
L V Efimova, and
T A Kazanskaia, and
V P Pukhlianko
May 1970,
European journal of pharmacology,
V A Frolov, and
E A Demurov, and
L V Efimova, and
T A Kazanskaia, and
V P Pukhlianko
January 1959,
Trudy Leningradskogo sanitarno-gigienicheskogo meditsinskogo instituta,
V A Frolov, and
E A Demurov, and
L V Efimova, and
T A Kazanskaia, and
V P Pukhlianko
February 1972,
Vrachebnoe delo,
V A Frolov, and
E A Demurov, and
L V Efimova, and
T A Kazanskaia, and
V P Pukhlianko
January 1960,
Terapevticheskii arkhiv,
