-transparent.png){kind=logo}
This paper reports the effect of two different doses (0.1 and 1 mg/g) of misonidazole on the radiosensitivity of human Na 11 melanoma transplanted into athymic nude mice. The mice were irradiated with 50 MeV neutrons. The end point was the in vitro colony-forming assay. Repair of potentially lethal damage following neutron irradiation was comparable to that observed after gamma irradiation. This repair was no longer detectable when 1 mg/g of misonidazole was used. When the 1 mg/g dose was used, the observed enhancement ratios after neutron irradiation were 1.52 for immediate plating and 1.87 for delayed plating. No toxic effect of the drug itself could be detected.
Related Publications
M Guichard, and
J Gueulette, and
M Octave-Prignot, and
A Wambersie, and
E P Malaise
January 1982,
Radiology,
M Guichard, and
J Gueulette, and
M Octave-Prignot, and
A Wambersie, and
E P Malaise
October 1993,
Gan to kagaku ryoho. Cancer & chemotherapy,
M Guichard, and
J Gueulette, and
M Octave-Prignot, and
A Wambersie, and
E P Malaise
May 1988,
Biological chemistry Hoppe-Seyler,
M Guichard, and
J Gueulette, and
M Octave-Prignot, and
A Wambersie, and
E P Malaise
January 1992,
Neoplasma,
M Guichard, and
J Gueulette, and
M Octave-Prignot, and
A Wambersie, and
E P Malaise
September 1988,
Gan to kagaku ryoho. Cancer & chemotherapy,
M Guichard, and
J Gueulette, and
M Octave-Prignot, and
A Wambersie, and
E P Malaise
January 1982,
International journal of radiation oncology, biology, physics,
M Guichard, and
J Gueulette, and
M Octave-Prignot, and
A Wambersie, and
E P Malaise
November 1983,
European journal of cancer & clinical oncology,
M Guichard, and
J Gueulette, and
M Octave-Prignot, and
A Wambersie, and
E P Malaise
January 1986,
Japanese journal of cancer research : Gann,
M Guichard, and
J Gueulette, and
M Octave-Prignot, and
A Wambersie, and
E P Malaise
January 1981,
Radiation research,
M Guichard, and
J Gueulette, and
M Octave-Prignot, and
A Wambersie, and
E P Malaise
April 1983,
The Japanese journal of experimental medicine,
