Biomaterial Database

Monte Carlo studies of the lateral organization of molecules in two-component lipid bilayers. 1980

E Freire, and B Snyder

The lateral organization of two-component phosphatidylcholine bilayers has been investigated using Monte Carlo calculations based upon non-ideality parameters deduced from the phase diagrams of these mixtures. The results are used to develop a quantitative description of the distribution and spatial localization of compositional regions along the bilayer plane in both the gel and liquid crystalline phases. In particular, a detailed analysis of the physical extension (lateral connectivity) and compactness of the compositional clusters is made. It is concluded that the chemical composition of the membrane, the physical state of the bilayer and the interaction energies between molecules greatly influence the lateral connectivity and compactness of compositional regions and that these parameters might play an important role in the formation of diffusional pathways along the membrane plane.

UI	MeSH Term	Description	Entries
D008051	Lipid Bilayers	Layers of lipid molecules which are two molecules thick. Bilayer systems are frequently studied as models of biological membranes.	Bilayers, Lipid,Bilayer, Lipid,Lipid Bilayer
D008433	Mathematics	The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Mathematic
D008968	Molecular Conformation	The characteristic three-dimensional shape of a molecule.	Molecular Configuration,3D Molecular Structure,Configuration, Molecular,Molecular Structure, Three Dimensional,Three Dimensional Molecular Structure,3D Molecular Structures,Configurations, Molecular,Conformation, Molecular,Conformations, Molecular,Molecular Configurations,Molecular Conformations,Molecular Structure, 3D,Molecular Structures, 3D,Structure, 3D Molecular,Structures, 3D Molecular
D010713	Phosphatidylcholines	Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	Choline Phosphoglycerides,Choline Glycerophospholipids,Phosphatidyl Choline,Phosphatidyl Cholines,Phosphatidylcholine,Choline, Phosphatidyl,Cholines, Phosphatidyl,Glycerophospholipids, Choline,Phosphoglycerides, Choline
D003201	Computers	Programmable electronic devices designed to accept data, perform prescribed mathematical and logical operations at high speed, and display the results of these operations.	Calculators, Programmable,Computer Hardware,Computers, Digital,Hardware, Computer,Calculator, Programmable,Computer,Computer, Digital,Digital Computer,Digital Computers,Programmable Calculator,Programmable Calculators