[Stimulating effect of certain chemical carcinogens on gastric organ cultures]. 1980

L M Shabad, and L A Savluchinskaia, and N I Golub'

Results of measuring the relative growth of the area surrounding the explants of nonibred rat embryonal stomach were studied after transplacental exposure to benz(a)pyrene (BP) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The embryonal tissue of the rat stomach is marked by high sensitivity to the carcinogens. This was manifested in better survival of the test cultures. The magniture of the relative growth of the explants exposed to transplacental MNNG exceeded, over the same period of culture, the control measurements by 2.5--3.5 times on the average, while on transplacental administration of BP the largest growth was recorded on the 6th day.

UI MeSH Term Description Entries
D008431 Maternal-Fetal Exchange Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission. Transplacental Exposure,Exchange, Maternal-Fetal,Exposure, Transplacental,Maternal Fetal Exchange
D008769 Methylnitronitrosoguanidine A nitrosoguanidine derivative with potent mutagenic and carcinogenic properties. Methylnitrosonitroguanidine,Nitrosomethylnitroguanidine,Nitrosonitromethylguanidine,MNNG,N-Methyl-N'-nitro-N-nitrosoguanidine,N Methyl N' nitro N nitrosoguanidine
D009924 Organ Culture Techniques A technique for maintenance or growth of animal organs in vitro. It refers to three-dimensional cultures of undisaggregated tissue retaining some or all of the histological features of the tissue in vivo. (Freshney, Culture of Animal Cells, 3d ed, p1) Organ Culture,Culture Technique, Organ,Culture Techniques, Organ,Organ Culture Technique,Organ Cultures
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001580 Benzopyrenes A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it. Benzpyrene
D013268 Stimulation, Chemical The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical. Chemical Stimulation,Chemical Stimulations,Stimulations, Chemical
D013270 Stomach An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM. Stomachs
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

L M Shabad, and L A Savluchinskaia, and N I Golub'
January 2002, Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer,
L M Shabad, and L A Savluchinskaia, and N I Golub'
January 1971, Voprosy onkologii,
L M Shabad, and L A Savluchinskaia, and N I Golub'
March 1972, Cancer research,
L M Shabad, and L A Savluchinskaia, and N I Golub'
October 1963, American journal of clinical pathology,
L M Shabad, and L A Savluchinskaia, and N I Golub'
April 1965, British journal of experimental pathology,
L M Shabad, and L A Savluchinskaia, and N I Golub'
August 1990, Xenobiotica; the fate of foreign compounds in biological systems,
L M Shabad, and L A Savluchinskaia, and N I Golub'
July 1969, Cancer research,
L M Shabad, and L A Savluchinskaia, and N I Golub'
January 1983, Basic life sciences,
L M Shabad, and L A Savluchinskaia, and N I Golub'
February 1986, Czasopismo stomatologiczne,
L M Shabad, and L A Savluchinskaia, and N I Golub'
October 1965, British journal of experimental pathology,
Copied contents to your clipboard!