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Superoxide dismutase (SOD) activity, the number of free radicals and pathomorphological changes were studied in lung and liver tissues of white rats with experimental paraquat poisoning. It was shown that SOD activity in the lungs and liver decreased and the number of free radicals rose. The inhibition of SOD activity after repeated administration of paraquat (1/10 of LD50) was more pronounced than in acute poisoning. Dystrophic and proliferative histomorphological changes characteristic for acute and chronic experiments and disturbed vascular permeability were revealed. It is suggested that the toxic action of paraquat on the animals is particularly consequent on the lack of SOD activity and enhancement of free radical processes.
V E Iakushko, and
G A Rodionov, and
L Nad'maĭteni, and
L M Ovsiannikova
September 1990,
Biomedical and environmental sciences : BES,
V E Iakushko, and
G A Rodionov, and
L Nad'maĭteni, and
L M Ovsiannikova
April 1972,
Archives of environmental health,
V E Iakushko, and
G A Rodionov, and
L Nad'maĭteni, and
L M Ovsiannikova
September 1984,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
V E Iakushko, and
G A Rodionov, and
L Nad'maĭteni, and
L M Ovsiannikova
January 1971,
Lo sperimentale,
V E Iakushko, and
G A Rodionov, and
L Nad'maĭteni, and
L M Ovsiannikova
January 1972,
Acta morphologica Academiae Scientiarum Hungaricae,
V E Iakushko, and
G A Rodionov, and
L Nad'maĭteni, and
L M Ovsiannikova
February 1967,
Biochemical pharmacology,
V E Iakushko, and
G A Rodionov, and
L Nad'maĭteni, and
L M Ovsiannikova
January 1976,
Patologia polska,
V E Iakushko, and
G A Rodionov, and
L Nad'maĭteni, and
L M Ovsiannikova
August 1970,
The Journal of pathology,
V E Iakushko, and
G A Rodionov, and
L Nad'maĭteni, and
L M Ovsiannikova
June 1984,
The American journal of forensic medicine and pathology,
V E Iakushko, and
G A Rodionov, and
L Nad'maĭteni, and
L M Ovsiannikova
January 1982,
Bulletin europeen de physiopathologie respiratoire,
