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An enriched population of isolated gastric parietal cells was obtained from canine gastric mucosa. Parietal cells incubated with [14C]arachidonic acid produced radiolabelled PGF2 alpha, PGE2, PGD2 and 6-keto PGF1 alpha (acid hydrolysis product of PGI2). The prostaglandin synthesis was inhibited by indomethacin. Prostaglandin production, as measured by gas chromatography-mass spectrometry demonstrated that PGF2 alpha was produced in the highest quantity followed by PGE2 and 6-keto PGF 1 alpha. This demonstrates that isolated prietal cells are capable of producing prostaglandins. Since prostaglandins have a potent effect on gastric acid secretion, local prostaglandin synthesis could modulate parietal cell function.
M L Skoglund, and
J G Gerber, and
R C Murphy, and
A S Nies
November 1988,
Prostaglandins,
M L Skoglund, and
J G Gerber, and
R C Murphy, and
A S Nies
November 1988,
Prostaglandins,
M L Skoglund, and
J G Gerber, and
R C Murphy, and
A S Nies
April 1985,
British journal of pharmacology,
M L Skoglund, and
J G Gerber, and
R C Murphy, and
A S Nies
May 1989,
The American journal of physiology,
M L Skoglund, and
J G Gerber, and
R C Murphy, and
A S Nies
October 1990,
Gastroenterologia Japonica,
M L Skoglund, and
J G Gerber, and
R C Murphy, and
A S Nies
November 1988,
The Biochemical journal,
M L Skoglund, and
J G Gerber, and
R C Murphy, and
A S Nies
June 1990,
Biochemical pharmacology,
M L Skoglund, and
J G Gerber, and
R C Murphy, and
A S Nies
May 1981,
Agents and actions,
M L Skoglund, and
J G Gerber, and
R C Murphy, and
A S Nies
January 1987,
Advances in prostaglandin, thromboxane, and leukotriene research,
M L Skoglund, and
J G Gerber, and
R C Murphy, and
A S Nies
May 1986,
The American journal of physiology,
