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A radioimmunoassay has been developed which enables accurate determination of haloperidol in human serum. Antiserum was prepared by immunizing guinea pigs with haloperidol (O-carboxymethyl)oxime derivative (III) coupled with bovine serum albumin. With the antiserum, 3H-haloperidol and dextran-coated charcoal, the assay of haloperidol in serum was possible over a concentration range of 1 to 50 ng/ml, using 0.1 ml of human serum without the need of an extraction procedure. Data obtained by radioimmunoassay are in good agreement with those obtained by gas chromatography. No appreciable cross-reactivity was observed neither with haloperidol metabolites nor with other butyrophenone neuroleptics. Serum levels of haloperidol in schizophrenic patients receiving single oral dosing (6 mg/subject) have also been determined.
H Suzuki, and
Y Minaki, and
M Iwaisaki, and
Y Sekine, and
A Kagemoto, and
Y Utsui, and
M Hashimoto, and
G Yagi, and
H Itoh
June 1984,
Radioisotopes,
H Suzuki, and
Y Minaki, and
M Iwaisaki, and
Y Sekine, and
A Kagemoto, and
Y Utsui, and
M Hashimoto, and
G Yagi, and
H Itoh
January 1977,
Life sciences,
H Suzuki, and
Y Minaki, and
M Iwaisaki, and
Y Sekine, and
A Kagemoto, and
Y Utsui, and
M Hashimoto, and
G Yagi, and
H Itoh
November 1981,
Life sciences,
H Suzuki, and
Y Minaki, and
M Iwaisaki, and
Y Sekine, and
A Kagemoto, and
Y Utsui, and
M Hashimoto, and
G Yagi, and
H Itoh
January 1981,
International pharmacopsychiatry,
H Suzuki, and
Y Minaki, and
M Iwaisaki, and
Y Sekine, and
A Kagemoto, and
Y Utsui, and
M Hashimoto, and
G Yagi, and
H Itoh
May 1990,
Journal of pharmaceutical sciences,
H Suzuki, and
Y Minaki, and
M Iwaisaki, and
Y Sekine, and
A Kagemoto, and
Y Utsui, and
M Hashimoto, and
G Yagi, and
H Itoh
January 1977,
The Journal of biological chemistry,
H Suzuki, and
Y Minaki, and
M Iwaisaki, and
Y Sekine, and
A Kagemoto, and
Y Utsui, and
M Hashimoto, and
G Yagi, and
H Itoh
August 1975,
Cancer research,
H Suzuki, and
Y Minaki, and
M Iwaisaki, and
Y Sekine, and
A Kagemoto, and
Y Utsui, and
M Hashimoto, and
G Yagi, and
H Itoh
November 1981,
Ceskoslovenska farmacie,
H Suzuki, and
Y Minaki, and
M Iwaisaki, and
Y Sekine, and
A Kagemoto, and
Y Utsui, and
M Hashimoto, and
G Yagi, and
H Itoh
January 1979,
The American journal of physiology,
H Suzuki, and
Y Minaki, and
M Iwaisaki, and
Y Sekine, and
A Kagemoto, and
Y Utsui, and
M Hashimoto, and
G Yagi, and
H Itoh
January 1976,
Horumon to rinsho. Clinical endocrinology,
