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To elucidate the pathogenetic mechanism of bacterial-allergical diseases and of reactions provoked by bacterial test substances (e.g. the intracutaneous test), it is necessary to analyse carefully various factors involved in these reactions. To try to separate toxic from immunological reactions minute amounts of peptidoglycan in four different preparations were applied to humans by intracutaneous injections. Peptidoglycan, an immunologically well defined wall components of almost all bacteria and which is therefore ubiquitous, was isolated from staphylococci and streptococci. The skin reactions were evaluated by macroscopical, microscopical and immunohistological observations, as well as by electromicroscopy and statistical means. Several findings indicate the involvement of immunological factors in the observed skin reactions. In some cases no measurable reaction was seen, whereas in others typical skin reactions occurred. Similar reactions were produced by the antigenically related peptidoglycans isolated from Staphylococcus aureus and Staphylococcus epidermis. These reactions differed, however, from those elicited by peptidoglycan preparations from Streptococcus pyogenes type A. Patients with chronic bacterial infections and who were injected by four bacterial preparations demonstrated a significant increase in delayed hypersensitivity reaction compared with two other groups of patients (atopic patients without chronic infection). Because of the very low test dose, necrotic skin reactions, which occur in animal experiments, were not observed.
J von Mayenburg, and
B Heymer, and
H Düngemann, and
K H Schleifer, and
H P Seidl, and
J Galle, and
A Neiss, and
S Borelli
January 1970,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
J von Mayenburg, and
B Heymer, and
H Düngemann, and
K H Schleifer, and
H P Seidl, and
J Galle, and
A Neiss, and
S Borelli
July 1976,
Journal of immunology (Baltimore, Md. : 1950),
J von Mayenburg, and
B Heymer, and
H Düngemann, and
K H Schleifer, and
H P Seidl, and
J Galle, and
A Neiss, and
S Borelli
February 1994,
Trends in microbiology,
J von Mayenburg, and
B Heymer, and
H Düngemann, and
K H Schleifer, and
H P Seidl, and
J Galle, and
A Neiss, and
S Borelli
January 2022,
Current medicinal chemistry,
J von Mayenburg, and
B Heymer, and
H Düngemann, and
K H Schleifer, and
H P Seidl, and
J Galle, and
A Neiss, and
S Borelli
March 2006,
Proceedings of the National Academy of Sciences of the United States of America,
J von Mayenburg, and
B Heymer, and
H Düngemann, and
K H Schleifer, and
H P Seidl, and
J Galle, and
A Neiss, and
S Borelli
April 1985,
Agents and actions,
J von Mayenburg, and
B Heymer, and
H Düngemann, and
K H Schleifer, and
H P Seidl, and
J Galle, and
A Neiss, and
S Borelli
December 2021,
Bulletin of experimental biology and medicine,
J von Mayenburg, and
B Heymer, and
H Düngemann, and
K H Schleifer, and
H P Seidl, and
J Galle, and
A Neiss, and
S Borelli
January 2016,
Methods in molecular biology (Clifton, N.J.),
J von Mayenburg, and
B Heymer, and
H Düngemann, and
K H Schleifer, and
H P Seidl, and
J Galle, and
A Neiss, and
S Borelli
September 2023,
Nature communications,
J von Mayenburg, and
B Heymer, and
H Düngemann, and
K H Schleifer, and
H P Seidl, and
J Galle, and
A Neiss, and
S Borelli
November 1993,
Infection and immunity,
