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Antigens cause an increase of the DNA synthesis in the spleen of mice as shown by the incorporation of [32P]orthophosphate and [3H]thymidine. In the present paper, the incorporation of [32P]orthophosphate into the single deoxymononucletides has been studied under influence of the antigen bovine serum albumin. For this purpose, the labelled DNA was decomposed to the deoxymononucleotides and their specific activities determined. Using [32P]orthophosphate, it was found that the activity of the DNA increased continuously during an observation period of 8 h. While after one hour the relative specific activity of dTMP was highest and that of dAMP lowest, the relative specific activities of the deoxymononucleotides had become equal after 8 h. Under the influence of bovine serum albumin, the incorporation of [32P]orthophosphate increased in he main band DNA as well as in the satellite DNA. The antigen had no effect on the distribution of the specific activities of the deoxymononucleotides.
W Uecker, and
D Kubsch, and
D Lutz, and
H Kröger
January 1982,
Arzneimittel-Forschung,
W Uecker, and
D Kubsch, and
D Lutz, and
H Kröger
January 1976,
Arzneimittel-Forschung,
W Uecker, and
D Kubsch, and
D Lutz, and
H Kröger
December 1970,
Archives internationales de physiologie et de biochimie,
W Uecker, and
D Kubsch, and
D Lutz, and
H Kröger
January 1976,
Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina,
W Uecker, and
D Kubsch, and
D Lutz, and
H Kröger
December 1980,
Revista espanola de fisiologia,
W Uecker, and
D Kubsch, and
D Lutz, and
H Kröger
August 1977,
Strahlentherapie,
W Uecker, and
D Kubsch, and
D Lutz, and
H Kröger
January 1980,
Shika gakuho. Dental science reports,
W Uecker, and
D Kubsch, and
D Lutz, and
H Kröger
July 1957,
Biochimica et biophysica acta,
W Uecker, and
D Kubsch, and
D Lutz, and
H Kröger
November 1984,
Analytical biochemistry,
W Uecker, and
D Kubsch, and
D Lutz, and
H Kröger
March 1954,
Biochimica et biophysica acta,
