Biomaterial Database

[Effect of dopamine on renal and intrarenal hemodynamics in unilateral ureteral occlusion]. 1980

H J Augustin, and H Huland

Renal and intrarenal hemodynamics were studied over a period of 6 months in the hydronephrotic dog kidney after unilateral complete ligation of the ureter. Already 7 hours after ligation renal blood flow was reduced. The intrarenal blood flow distribution changed with a massive reduction in cortical and only slight decrease in medullary perfusion. This alteration of intrarenal blood flow resulted in a change of the compartment fractions. Dopamine, applied intravenously in a dose of 4 micrograms kg-1 min-1, induced a vasodiilation of the obstructed kidney during the whole period of investigation. Especially the reduced cortical blood flow could be improved by the application of dopamine.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D004298	Dopamine	One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.	Hydroxytyramine,3,4-Dihydroxyphenethylamine,4-(2-Aminoethyl)-1,2-benzenediol,Dopamine Hydrochloride,Intropin,3,4 Dihydroxyphenethylamine,Hydrochloride, Dopamine
D006439	Hemodynamics	The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.	Hemodynamic
D006869	Hydronephrosis	Abnormal enlargement or swelling of a KIDNEY due to dilation of the KIDNEY CALICES and the KIDNEY PELVIS. It is often associated with obstruction of the URETER or chronic kidney diseases that prevents normal drainage of urine into the URINARY BLADDER.	Hydronephroses
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014517	Ureteral Obstruction	Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.	Obstruction, Ureteral,Obstructions, Ureteral,Ureteral Obstructions