Biomaterial Database

The efffect of sustained +Gz acceleration on extravascular lung water content in domestic fowl. 1980

W J Weidner, and L F Hoffman

In order to examine the effects of sustained acceleration on pulmonary fluid balance, chickens were centrifuged at low sustained +G acceleration (LSG) intensities of +3Gz or +4Gz or high sustained +G acceleration (HSG) at +6Gz for varying periods. Animals were exposed to acceleration on a hydraulic-driven centrifuge. Controls (Group I) were not centrifuged. The vascular lungs were rapidly excised after centrifugation, and the extravascular lung water content (EVLW) was measured. EVLW in Group I animals = 2.19 +/- 0.38 g/g. Results indicate that positive acceleration elevated in animals exposed to +4Gz for 60 min (Group III). In this group, EVLW = 3.01 +/- 1.07 g/g. This increase is largely attributable to an elevated EVLW in those animals which died as a result of centrifugation, in which EVLW = 3.90 +/- 1.04 g/g. Exposure to +3Gz for 120 min (Group II) or +6Gz for periods up to 50 min (Group IV) did not produce significant elevations in EVLW in either group as a whole, but EVLW in those Group II animals which died as a result of centrifugation was significantly elevated. EVLW in these animals = 2.87 +/- 0.21 g/g. We conclude that pulmonary edema caused by centrifugation is dependent on both magnitude and duration of G force.

UI	MeSH Term	Description	Entries
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D008297	Male		Males
D011654	Pulmonary Edema	Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.	Wet Lung,Edema, Pulmonary,Edemas, Pulmonary,Pulmonary Edemas,Lung, Wet,Lungs, Wet,Wet Lungs
D002199	Capillary Permeability	The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.	Microvascular Permeability,Permeability, Capillary,Permeability, Microvascular,Vascular Permeability,Capillary Permeabilities,Microvascular Permeabilities,Permeabilities, Capillary,Permeabilities, Microvascular,Permeabilities, Vascular,Permeability, Vascular,Vascular Permeabilities
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D005260	Female		Females
D006112	Gravitation	Acceleration produced by the mutual attraction of two masses, and of magnitude inversely proportional to the square of the distance between the two centers of mass. It is also the force imparted by the earth, moon, or a planet to an object near its surface. (From NASA Thesaurus, 1988)	G Force,Gravistimulation,Gravity,Force, G,G Forces,Gravities
D006439	Hemodynamics	The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.	Hemodynamic
D000054	Acceleration	An increase in the rate of speed.	Accelerations
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia