Biomaterial Database

Mirex kinetics in chickens. 1980

F A Ahrens, and D C Dyer, and W E Lloyd

Mirex kinetics were determined in chickens after a single dose of 30 mg/kg iv or 300 mg/kg orally. The decline in blood concentrations was biphasic and suggested uptake of mirex by "fast" and "slow" tissue compartments, with the greatest accumulation in fat and skin 2 wk after administration. Less than 1% of the dose was excreted in 2 wk. Mirex depletion rates in skin and fat were determined in growing chicks fed 1 or 10 ppm mirex in the diet for 1 wk. Calculated disappearance half-times for mirex were 24.8 in skin and 31.5 d in fat. The decrease in tissue concentrations was attributed to dilution in tissue mass accompanying the rapid growth rate rather than to excretion of mirex. The results do not indicate that avian species eliminate mirex more efficently than mammals.

UI	MeSH Term	Description	Entries
D007306	Insecticides	Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.	Insecticide
D008917	Mirex	An organochlorine insecticide that is carcinogenic.
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D005243	Feces	Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
D000273	Adipose Tissue	Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.	Fatty Tissue,Body Fat,Fat Pad,Fat Pads,Pad, Fat,Pads, Fat,Tissue, Adipose,Tissue, Fatty
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012867	Skin	The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D014018	Tissue Distribution	Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.	Distribution, Tissue,Distributions, Tissue,Tissue Distributions