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The effects of long-term amphetamine treatment were examined on self-stimulation responding from the substantia nigra. Rates of self-stimulation responding were substantially depressed among rats chronically treated with amphetamine and tested in the absence of the drug. When rats were subsequently retested after a two day hiatus in which they received imipramine or amitriptyline, the post-amphetamine depression of rates of self-stimulation responding was mitigated. The efficacy of imipramine and amitriptyline in reversing the post-amphetamine depression of self-stimulation responding was also evident during a continuation of the drug (imipramine or amitriptyline)/test sequence, for seven test sessions. The results of the present investigation were related to changes in dopamine and acetylcholine neurotransmission following long-term amphetamine treatement.
L Kokkinidis, and
R M Zacharko, and
P A Predy
January 1994,
Neurobiology (Budapest, Hungary),
L Kokkinidis, and
R M Zacharko, and
P A Predy
February 1976,
Behavioral biology,
L Kokkinidis, and
R M Zacharko, and
P A Predy
March 1978,
The Journal of pharmacology and experimental therapeutics,
L Kokkinidis, and
R M Zacharko, and
P A Predy
January 2013,
PloS one,
L Kokkinidis, and
R M Zacharko, and
P A Predy
November 1976,
Life sciences,
L Kokkinidis, and
R M Zacharko, and
P A Predy
August 1979,
Brain research,
L Kokkinidis, and
R M Zacharko, and
P A Predy
January 1975,
Behavioral biology,
L Kokkinidis, and
R M Zacharko, and
P A Predy
January 1980,
Psychopharmacology,
L Kokkinidis, and
R M Zacharko, and
P A Predy
January 2008,
Parkinsonism & related disorders,
L Kokkinidis, and
R M Zacharko, and
P A Predy
November 1973,
Experimental neurology,
