Biomaterial Database

Necrotizing lesions in Sjögren's syndrome. II. An electron microscopic study. 1980

H Friedman, and A Sesso

Further evidences about necrotizing lesions in Sjögren's syndrome are presented. Electron microscopic studies disclosed acinar replacement by a mucus-containing lake surrounded by remnant myoepithelial cells. Interepithelial lymphocytes infiltrate the acinar walls in adjacent areas and macrophages bearing mucoid material within cytopasmic vacuoles were found in the interstitium. The significance of these findings in the natural history of Sjögren's syndrome is discussed.

UI	MeSH Term	Description	Entries
D008214	Lymphocytes	White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.	Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D009336	Necrosis	The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012469	Salivary Glands	Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).	Gland, Salivary,Glands, Salivary,Salivary Gland
D012859	Sjogren's Syndrome	Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.	Sicca Syndrome,Sjogren Syndrome,Sjogrens Syndrome,Syndrome, Sicca,Syndrome, Sjogren's