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The authors report on 21 cases of self-induced water intoxication and cite 25 others in the literature. Three of their patients demonstrated at least temporary inappropriate antidiuretic hormone secretion, 3 were receiving a diuretic, and the other 15 appeared to have "pure" water intoxication. Fifteen patients were receiving a psychotropic medication. Self-induced water intoxication appears to be more common in schizophrenic patients than is generally realized and should be suspected in any schizophrenic patient who develops convulsions or coma. Hyperdopaminergic CNS activity may be involved, and the authors suggest a possible mechanism similar to that for tardive dyskinesia.
W O Smith, and
M L Clark
December 1987,
Fortschritte der Neurologie-Psychiatrie,
W O Smith, and
M L Clark
March 1976,
Canadian Medical Association journal,
W O Smith, and
M L Clark
October 2002,
European psychiatry : the journal of the Association of European Psychiatrists,
W O Smith, and
M L Clark
March 1985,
The Journal of nervous and mental disease,
W O Smith, and
M L Clark
September 1984,
The Journal of nervous and mental disease,
W O Smith, and
M L Clark
January 1985,
The Journal of clinical psychiatry,
W O Smith, and
M L Clark
October 1993,
Psychological reports,
W O Smith, and
M L Clark
October 1984,
The American journal of psychiatry,
W O Smith, and
M L Clark
August 1992,
Clinical neuropharmacology,
W O Smith, and
M L Clark
March 1987,
The Australian and New Zealand journal of psychiatry,
