Biomaterial Database

Hypothermia after cardiopulmonary bypass in man: amelioration by nitroprusside-induced vasodilation during rewarming. 1980

C R Noback, and J H Tinker

The incidence, time course, and magnitude of hypothermia following apparently adequate rewarming from hypothermic cardiopulmonary bypass (defined as a nasopharyngeal temperature [NPT] of 37 C) were studied in 20 adult patients (Group I). In each patient a decrease in NPT (averaging 2.6 +/- .2 C) occurred during the 80-min intraoperative postbypass period. The NPT had stabilized approximately 45 min after the end of bypass. Eight additional patients (Group II) received pharmacologic vasodilation with nitroprusside during the rewarming period. Pump flow was increased as nitroprusside was infused to maintain mean arterial pressure greater than or equal to 70 torr. Group II patients maintained NPT significantly better in the postbypass period than did Group I patients (NPT decrease of 1.5 +/- .4 C, P < 0.01, a 42 per cent improvement). As in Group I, NPT in Group II had stabilized 45 min after bypass. Ambient air temperatures between 18 and 23 C had no effect on NPT decrease. Presumed peripheral heat delivery was found to be greater in Group II. It is concluded that postbypass NPT decreases occurred in all patients, but that these decreases were significantly lessened by pharmacologic vasodilation plus deliberately increased pump flow during rewarming on bypass.

UI	MeSH Term	Description	Entries
D007036	Hypothermia, Induced	Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries.	Induced Hypothermia,Mild Hypothermia, Induced,Moderate Hypothermia, Induced,Targeted Temperature Management,Therapeutic Hypothermia,Hypothermia, Therapeutic,Induced Mild Hypothermia,Induced Mild Hypothermias,Induced Moderate Hypothermia,Induced Moderate Hypothermias,Mild Hypothermias, Induced,Moderate Hypothermias, Induced,Targeted Temperature Managements
D009305	Nasopharynx	The top portion of the pharynx situated posterior to the nose and superior to the SOFT PALATE. The nasopharynx is the posterior extension of the nasal cavities and has a respiratory function.	Rhinopharynx,Choanae,Nasopharynges,Nasopharynxes,Rhinopharynges,Rhinopharynxes
D009599	Nitroprusside	A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.	Nitroferricyanide,Sodium Nitroprusside,Cyanonitrosylferrate,Ketostix,Naniprus,Nipride,Nipruton,Nitriate,Nitropress,Nitroprussiat Fides,Nitroprusside, Disodium Salt,Nitroprusside, Disodium Salt, Dihydrate,Disodium Salt Nitroprusside,Nitroprusside, Sodium
D002315	Cardiopulmonary Bypass	Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.	Heart-Lung Bypass,Bypass, Cardiopulmonary,Bypass, Heart-Lung,Bypasses, Cardiopulmonary,Bypasses, Heart-Lung,Cardiopulmonary Bypasses,Heart Lung Bypass,Heart-Lung Bypasses
D005292	Ferricyanides	Inorganic salts of the hypothetical acid, H3Fe(CN)6.
D006358	Hot Temperature	Presence of warmth or heat or a temperature notably higher than an accustomed norm.	Heat,Hot Temperatures,Temperature, Hot,Temperatures, Hot
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D014034	Toes	Any one of five terminal digits of the vertebrate FOOT.	Toe
D014664	Vasodilation	The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.	Vasodilatation,Vasorelaxation,Vascular Endothelium-Dependent Relaxation,Endothelium-Dependent Relaxation, Vascular,Relaxation, Vascular Endothelium-Dependent,Vascular Endothelium Dependent Relaxation