Regional deposition of inhaled 137 Cs-labeled monodisperse and polydisperse aluminosilicate aerosols in Syrian hamsters. 1978

R L Thomas, and O G Raabe

Two groups of eighty Syrian hamsters were exposed to aerosols of 137Cs-labeled fused aluminosilicate particles. One group was exposed to a monodisperse aerosol with AMAD (activity median aerodynamic diameter) of 1.53 micron and sigma g (geometric standard deviation) of 1.15. The other group was exposed to a polydisperse aerosol with AMAD of 1.87 micron and sigma g of 1.46. After exposure, the hamsters were killed and carefully dissected and tissues were assayed for 137Cs to determine regional deposition of the inhaled aerosols. The relative lung deposition was similar for the two groups and was estimated as 9.5% of the inhaled aerosols. The right apical lobe consistently contained more activity and the right cardiac and right diaphragmatic lobes less activity on a per gram lung weight basis than the total lung.

UI MeSH Term Description Entries
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008297 Male Males
D008647 Mesocricetus A genus in the order Rodentia and family Cricetidae. One species, Mesocricetus auratus or golden hamster is widely used in biomedical research. Hamsters, Golden,Hamsters, Golden Syrian,Hamsters, Syrian,Mesocricetus auratus,Syrian Golden Hamster,Syrian Hamster,Golden Hamster,Golden Hamster, Syrian,Golden Hamsters,Golden Syrian Hamsters,Hamster, Golden,Hamster, Syrian,Hamster, Syrian Golden,Syrian Hamsters
D010316 Particle Size Relating to the size of solids. Particle Sizes,Size, Particle,Sizes, Particle
D012137 Respiratory System The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about. Respiratory Tract,Respiratory Systems,Respiratory Tracts,System, Respiratory,Tract, Respiratory
D002588 Cesium Radioisotopes Unstable isotopes of cesium that decay or disintegrate emitting radiation. Cs atoms with atomic weights of 123, 125-132, and 134-145 are radioactive cesium isotopes. Radioisotopes, Cesium
D005260 Female Females
D006224 Cricetinae A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS. Cricetus,Hamsters,Hamster
D000336 Aerosols Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents. Aerosol
D000538 Aluminum Silicates Any of the numerous types of clay which contain varying proportions of Al2O3 and SiO2. They are made synthetically by heating aluminum fluoride at 1000-2000 degrees C with silica and water vapor. (From Hawley's Condensed Chemical Dictionary, 11th ed) Aluminum Silicate,Silicate, Aluminum,Silicates, Aluminum

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