BIOMAT Database Logo BIOMAT Database Logo

Linking the kallikrein and renin systems via activation of inactive renin: new data and a hypothesis. 1978

J E Sealey, and S A Atlas, and J H Laragh

UI MeSH Term Description Entries
D007610 Kallikreins Proteolytic enzymes from the serine endopeptidase family found in normal blood and urine. Specifically, Kallikreins are potent vasodilators and hypotensives and increase vascular permeability and affect smooth muscle. They act as infertility agents in men. Three forms are recognized, PLASMA KALLIKREIN (EC 3.4.21.34), TISSUE KALLIKREIN (EC 3.4.21.35), and PROSTATE-SPECIFIC ANTIGEN (EC 3.4.21.77). Kallikrein,Kininogenase,Callicrein,Dilminal,Kallidinogenase,Kalliginogenase,Kallikrein A,Kallikrein B',Kallikrein Light Chain,Kinin-Forming Enzyme,Padutin,alpha-Kallikrein,beta-Kallikrein,beta-Kallikrein B,Enzyme, Kinin-Forming,Kinin Forming Enzyme,Light Chain, Kallikrein,alpha Kallikrein,beta Kallikrein,beta Kallikrein B
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D007705 Kinins A generic term used to describe a group of polypeptides with related chemical structures and pharmacological properties that are widely distributed in nature. These peptides are AUTACOIDS that act locally to produce pain, vasodilatation, increased vascular permeability, and the synthesis of prostaglandins. Thus, they comprise a subset of the large number of mediators that contribute to the inflammatory response. (From Goodman and Gilman's The Pharmacologic Basis of Therapeutics, 8th ed, p588) Kinin
D012083 Renin A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19. Angiotensin-Forming Enzyme,Angiotensinogenase,Big Renin,Cryorenin,Inactive Renin,Pre-Prorenin,Preprorenin,Prorenin,Angiotensin Forming Enzyme,Pre Prorenin,Renin, Big,Renin, Inactive
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D001800 Blood Specimen Collection The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc. Blood Specimen Collections,Collection, Blood Specimen,Collections, Blood Specimen,Specimen Collection, Blood,Specimen Collections, Blood
D003080 Cold Temperature An absence of warmth or heat or a temperature notably below an accustomed norm. Cold,Cold Temperatures,Temperature, Cold,Temperatures, Cold
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000809 Angiotensins Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANGIOTENSIN SYSTEM. These include angiotensins derived naturally from precursor ANGIOTENSINOGEN, and those synthesized. Angiotensin
D014661 Vasoconstriction The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE. Vasoconstrictions

Related Publications

J E Sealey, and S A Atlas, and J H Laragh
Role of glandular kallikrein in the activation process of human plasma inactive renin.
January 1983, Hypertension (Dallas, Tex. : 1979),
J E Sealey, and S A Atlas, and J H Laragh
Kallikrein and plasmin as activators of inactive renin.
January 1978, Lancet (London, England),
J E Sealey, and S A Atlas, and J H Laragh
Isolation of completely inactive plasma prorenin and its activation by kallikreins. A possible new link between renin and kallikrein.
August 1979, Biochimica et biophysica acta,
J E Sealey, and S A Atlas, and J H Laragh
[Activation of inactive renin].
November 1983, Horumon to rinsho. Clinical endocrinology,
J E Sealey, and S A Atlas, and J H Laragh
Relationship between urinary kallikrein excretion and the extent of circulating inactive renin activation by the kidney.
January 1987, Agents and actions. Supplements,
J E Sealey, and S A Atlas, and J H Laragh
Partial purification of prorenin and activation by kallikreins: a possible new link between renin and kallikrein systems.
January 1979, Advances in experimental medicine and biology,
J E Sealey, and S A Atlas, and J H Laragh
The renin--kallikrein--prostaglandin system: plasma active and inactive renin and urinary kallikrein during prostacyclin infusion in man.
December 1980, Prostaglandins and medicine,
J E Sealey, and S A Atlas, and J H Laragh
[The responses of active and inactive plasma renin to various conditions in normal subjects and the role of renal or plasma kallikrein in activation of inactive renin].
August 1982, Nihon Naibunpi Gakkai zasshi,
J E Sealey, and S A Atlas, and J H Laragh
Plasma active renin, inactive renin and kallikrein in patients with disseminated intravascular coagulation.
May 1991, Journal of the Formosan Medical Association = Taiwan yi zhi,
J E Sealey, and S A Atlas, and J H Laragh
The reversible activation of inactive renin in human plasma: role of acid and of plasma kallikrein and plasmin.
January 1982, Clinical and experimental hypertension. Part A, Theory and practice,
Copied contents to your clipboard!