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The percentages of labelled lymphocytes in smear preparations of mouse thymus were higher than those in similar preparations of mesenteric lymph nodes with either generally labelled tritiated deoxycytidine, [3H]CdR, or tritiated thymidine, [3H]TdR. Lymphocytes in the thymus cortex and in germinal centres of mesenteric lymph nodes were intensely labelled with [3H]CdR, whereas with [3H]TdR lymphocytes in the peripheral region of thymus and medullary cords of mesenteric lymph nodes were heavily labelled. The majority of lymphocytes in thymic cortex and germinal centres of mesenteric lymph nodes were labelled weakly with [3H]TdR. Thus, labelling patterns with [3H]CdR differed from those with [3H]TdR in lymphoid tissues of the mouse. Mouse lymphocytes can utilize [3H]CdR as a precursor molecule for cytosine and thymine in DNA. The ratio of radioactivity of thymine to that of cytosine was measured biochemically in DNA extracted from lymphocytes labelled with [3H]CdR. This radioativity ratio in thymus was higher than that in mesenteric lymph nodes. These results suggest that the metabolic activities of utilizing CdR for DNA synthesis differ within lymphocyte populations in various lymphoid tissues in the mouse.
K Hamatani, and
M Amano
December 1973,
Revue canadienne de biologie,
K Hamatani, and
M Amano
September 1975,
Immunology,
K Hamatani, and
M Amano
August 1958,
Experimental cell research,
K Hamatani, and
M Amano
December 1974,
Revue canadienne de biologie,
K Hamatani, and
M Amano
June 1973,
Annales de genetique,
K Hamatani, and
M Amano
October 1978,
Virchows Archiv. B, Cell pathology,
K Hamatani, and
M Amano
June 1983,
Cancer letters,
K Hamatani, and
M Amano
January 1983,
Acta histochemica. Supplementband,
K Hamatani, and
M Amano
March 1972,
Cell and tissue kinetics,
K Hamatani, and
M Amano
January 1988,
Cellular and molecular biology,
