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Maternal and foetal plasma bupivacaine concentrations were assayed following segmental epidural analgesia during the first stage of 14 normal labours. Analgesia was accomplished with 20 mg of 0.5% bupivacaine. 10 mothers received only one dose and four mothers two doses. The maternal and foetal plasma bupivacaine levels remained very low and the foetomaternal ratios were about 1:4 during the labour. At delivery, the foeto-maternal ratio increased, showing that the decline of bupivacaine concentrations is slower in foetal than in maternal plasma.
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