Biomaterial Database

Platelet and plasma serotonin in glomerulonephritis. III: The nephritis of systemic lupus erythematosus. 1980

A Parbtani, and G Frampton, and V Yewdall, and N Kasai, and J S Cameron

Intraplatelet and plasma serotonin levels were measured in 269 samples from 44 patients with systemic lupus erythematosus (SLE) and clinical nephritis. The intraplatelet serotonin levels were depressed and the plasma serotonin levels were raised in lupus nephritis. There was a strong correlation between both lowered intraplatelet serotonin concentration and raised plasma "serotonin", and the overall clinical activity of the disease. This correlation was also observed in the majority of individual patients studied serially; the platelet serotonin levels correlated with both clinical and immunological tests. Serotonin uptake by platelets was significantly diminished, but there was no correlation between serotonin uptake and platelet serotonin levels. There was, however, a correlation between the amount of platelet-aggregating material in the serum and depression of intraplatelet serotonin. This study provides further evidence of in vivo platelet activation in SLE nephritis, and provides a measure of the activation in relation to the clinical and immunological activity of the disease.

UI	MeSH Term	Description	Entries
D008180	Lupus Erythematosus, Systemic	A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.	Libman-Sacks Disease,Lupus Erythematosus Disseminatus,Systemic Lupus Erythematosus,Disease, Libman-Sacks,Libman Sacks Disease
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009393	Nephritis	Inflammation of any part of the KIDNEY.	Nephritides
D010974	Platelet Aggregation	The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.	Aggregation, Platelet
D010976	Platelet Count	The number of PLATELETS per unit volume in a sample of venous BLOOD.	Blood Platelet Count,Blood Platelet Number,Platelet Number,Blood Platelet Counts,Blood Platelet Numbers,Count, Blood Platelet,Count, Platelet,Counts, Blood Platelet,Counts, Platelet,Number, Blood Platelet,Number, Platelet,Numbers, Blood Platelet,Numbers, Platelet,Platelet Count, Blood,Platelet Counts,Platelet Counts, Blood,Platelet Number, Blood,Platelet Numbers,Platelet Numbers, Blood
D001792	Blood Platelets	Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.	Platelets,Thrombocytes,Blood Platelet,Platelet,Platelet, Blood,Platelets, Blood,Thrombocyte
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D005260	Female		Females
D005921	Glomerulonephritis	Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.	Bright Disease,Kidney Scarring,Glomerulonephritides,Scarring, Kidney