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The penetration of amoxicillin into cerebrospinal fluid (CFS) in the presence of meningeal inflammation was evaluated in patients with tuberculous meningitis. Serum and CSF concentrations of amoxicillin were measured at 2 h in nine patients who received a 1-g oral dose and at 1.5 and 4 h in ten patients who received a 2-g intravenous injection of sodium amoxicillin. After the oral dose, CSF concentrations ranged from 0.1 to 1.5 mug/ml. After the intravenous injection, CSF concentrations ranged from 2.9 to 40.0 mug/ml at 1.5 h and from 2.6 to 27.0 mug/ml at 4 h. These data on penetration suggest that parenterally administered sodium amoxicillin may be of value in the therapy of acute bacterial meningitis.
L J Strausbaugh, and
N I Girgis, and
I A Mikhail, and
D C Edman, and
W F Miner, and
M W Yassin
January 1981,
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M W Yassin
January 1993,
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L J Strausbaugh, and
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M W Yassin
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August 1988,
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L J Strausbaugh, and
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L J Strausbaugh, and
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D C Edman, and
W F Miner, and
M W Yassin
April 1986,
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L J Strausbaugh, and
N I Girgis, and
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L J Strausbaugh, and
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D C Edman, and
W F Miner, and
M W Yassin
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L J Strausbaugh, and
N I Girgis, and
I A Mikhail, and
D C Edman, and
W F Miner, and
M W Yassin
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Antimicrobial agents and chemotherapy,
L J Strausbaugh, and
N I Girgis, and
I A Mikhail, and
D C Edman, and
W F Miner, and
M W Yassin
May 1982,
Neurochirurgia,
