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The effect of cimetidine on human microsomal drug metabolism was studied. In five of six healthy volunteers therapeutic doses of cimetidine prolonged the half-life of antipyrine (range 12-37%; p < 0.05). Its clearance was decreased in five subjects (range 2-18%) and was increased in one subject (15%), the changes not being statistically significant. The volume of distribution increased on average by about 14% (range 9--19%; p < 0.001). Cimetidine in vitro inhibited the hydroxylation of benzo(a)pyrene and coumarin, as well as the O-deethylation of 7-ethoxycoumarin, by homogenised liver biopsies. The in vitro studies suggest that the effect of cimetidine on antipyrine elimination is due to inhibition of microsomal drug metabolism, which may prove an important drug interaction.
J Puurunen, and
E Sotaniemi, and
O Pelkonen
October 1982,
European journal of clinical investigation,
J Puurunen, and
E Sotaniemi, and
O Pelkonen
May 1979,
European journal of pharmacology,
J Puurunen, and
E Sotaniemi, and
O Pelkonen
November 1980,
Biochemical pharmacology,
J Puurunen, and
E Sotaniemi, and
O Pelkonen
January 1984,
International archives of occupational and environmental health,
J Puurunen, and
E Sotaniemi, and
O Pelkonen
January 1967,
Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie,
J Puurunen, and
E Sotaniemi, and
O Pelkonen
March 1983,
Die Medizinische Welt,
J Puurunen, and
E Sotaniemi, and
O Pelkonen
June 1984,
Mechanisms of ageing and development,
J Puurunen, and
E Sotaniemi, and
O Pelkonen
May 1982,
Xenobiotica; the fate of foreign compounds in biological systems,
J Puurunen, and
E Sotaniemi, and
O Pelkonen
January 1982,
Drug metabolism and disposition: the biological fate of chemicals,
J Puurunen, and
E Sotaniemi, and
O Pelkonen
October 1982,
British journal of clinical pharmacology,
