Biomaterial Database

Studies on the distribution of (1-14C) pantothenic acid in rats. 1980

K Pietrzik, and D Hornig

The distribution of (1-14C) pantothenic acid was studied in two different experiments with rats. Single dose kinetics were carried out over a period of 168 hours. In this experiment it could be shown that besides the urinary and faecal output a third route of excretion exists: the respiratory pathway. The tissues with the highest retention capacity were the kidneys, pituitary gland, heart, muscle, liver and the adrenal glands. In a second experiment - performed as steady state study, lasting 35 days - during the investigated period and finally in the steady state the above mentioned tissues showed the highest affinity for pantothenic acid, indicating an intensive metabolism of this vitamin. These results are discussed, especially towards pantothenic acid and acetyl coenzyme A-depending functions.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010205	Pantothenic Acid	A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.	Vitamin B 5,Calcium Pantothenate,Dexol,Vitamin B5,Zinc Pantothenate,B 5, Vitamin,B5, Vitamin,Pantothenate, Calcium,Pantothenate, Zinc
D001944	Breath Tests	Any tests done on exhaled air.	Breathalyzer Tests,Breath Test,Breathalyzer Test,Test, Breath,Test, Breathalyzer,Tests, Breath,Tests, Breathalyzer
D005243	Feces	Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014018	Tissue Distribution	Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.	Distribution, Tissue,Distributions, Tissue,Tissue Distributions
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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