BIOMAT Database Logo BIOMAT Database Logo

In vivo and in vitro cell-mediated immunity to tetanus toxoid in adults. 1980

R D Fairshter, and D B Thornton, and H R Gottschalk, and L M Slater, and S P Galant

The purpose of this study was to evaluate tetanus toxoid (TT) as an indicator of cutaneous delayed hypersensitivity (CDH) in adults. Fifty-two normal subjects, aged 25 to 64 yr, were skin tested with TT and streptokinase-streptodornase (SK/SD). Lymphocyte transformation was studied in seven normal TT reactors, four normal TT nonreactors, and seven hospitalized anergic patients. CDH was common with both TT and SK/SD; 90% of the adults, aged 25 to 39 yr, had CDH reactions to TT and 79% had CDH reactions to SK/SD. In adults aged 40 to 64 yr, 75% had DCH reactions to TT and 59% had CDH reactions to SK/SD. Lymphocyte transformation to TT correlated well with TT skin-test results. Punch biopsy specimens of TT reactions 48 hr after skin testing demonstrated DCH. We conclude that TT is an excellent antigen for assessing the presence or absence of CDH in adults aged 25 to 64 yr.

UI MeSH Term Description Entries
D006968 Hypersensitivity, Delayed An increased reactivity to specific antigens mediated not by antibodies but by sensitized T CELLS. Hypersensitivity, Tuberculin-Type,Hypersensitivity, Type IV,Tuberculin-Type Hypersensitivity,Type IV Hypersensitivity,Delayed Hypersensitivity,Delayed Hypersensitivities,Hypersensitivity, Tuberculin Type,Tuberculin Type Hypersensitivity,Tuberculin-Type Hypersensitivities,Type IV Hypersensitivities
D007111 Immunity, Cellular Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role. Cell-Mediated Immunity,Cellular Immune Response,Cell Mediated Immunity,Cell-Mediated Immunities,Cellular Immune Responses,Cellular Immunities,Cellular Immunity,Immune Response, Cellular,Immune Responses, Cellular,Immunities, Cell-Mediated,Immunities, Cellular,Immunity, Cell-Mediated,Response, Cellular Immune
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008213 Lymphocyte Activation Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION. Blast Transformation,Blastogenesis,Lymphoblast Transformation,Lymphocyte Stimulation,Lymphocyte Transformation,Transformation, Blast,Transformation, Lymphoblast,Transformation, Lymphocyte,Activation, Lymphocyte,Stimulation, Lymphocyte
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D003208 Concanavalin A A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

R D Fairshter, and D B Thornton, and H R Gottschalk, and L M Slater, and S P Galant
Use of tetanus toxoid for testing cell-mediated immunity.
October 1982, Australian and New Zealand journal of medicine,
R D Fairshter, and D B Thornton, and H R Gottschalk, and L M Slater, and S P Galant
Specific in vivo and in vitro antibody response to tetanus toxoid immunization.
September 1982, Clinical and experimental immunology,
R D Fairshter, and D B Thornton, and H R Gottschalk, and L M Slater, and S P Galant
Reduced in vitro production of anti-tetanus toxoid antibody after repeated in vivo immunization with tetanus toxoid.
February 1979, Journal of immunology (Baltimore, Md. : 1950),
R D Fairshter, and D B Thornton, and H R Gottschalk, and L M Slater, and S P Galant
Delayed hypersensitivity to tetanus toxoid in man: in vivo and in vitro studies.
October 1983, Pathology,
R D Fairshter, and D B Thornton, and H R Gottschalk, and L M Slater, and S P Galant
Tetanus toxoid for adults.
February 1997, Lancet (London, England),
R D Fairshter, and D B Thornton, and H R Gottschalk, and L M Slater, and S P Galant
Tetanus toxoid for adults.
December 1996, Lancet (London, England),
R D Fairshter, and D B Thornton, and H R Gottschalk, and L M Slater, and S P Galant
Cell mediated immunity to recall antigens in vivo and in vitro.
June 1977, Irish journal of medical science,
R D Fairshter, and D B Thornton, and H R Gottschalk, and L M Slater, and S P Galant
Human auto-antiidiotypes regulating T cell-mediated reactivity to tetanus toxoid.
February 1984, The Journal of clinical investigation,
R D Fairshter, and D B Thornton, and H R Gottschalk, and L M Slater, and S P Galant
Effect of Preexisting Immunity to Tetanus Toxoid on the Efficacy of Tetanus Toxoid-Conjugated Heroin Vaccine in Mice.
June 2021, Vaccines,
R D Fairshter, and D B Thornton, and H R Gottschalk, and L M Slater, and S P Galant
In vivo and in vitro cell-mediated immunity in tuberculous meningitis.
May 1982, Journal of clinical & laboratory immunology,
Copied contents to your clipboard!