-transparent.png){kind=logo}
Within 6 hr of the intravenous administration of radiolabeled 1,25(OH)2D3 to five normal vitamin D-replete human subjects, 15.6% of the injected dose appeared in bile as polar metabolites of 1,25(OH)2D3. Of the injected dose, 27% and 7.5% appeared in the feces and urine, respectively, at 24 hr. In another two subjects, biliary radioactivity was sampled at two jejunal sites separated by a distance of 40 cm; a 24.8% decrease in radioactivity over this segment of bowel was noted. These data demonstrate that products of 1,25(OH)2D3 are excreted in normal human bile. Furthermore, these products are reabsorbed as such or as free 1,25(OH)2D3 in the intestine and re-excreted as polar products in bile. Our data suggest that there is an enterohepatic circulation of the products of 1,25(OH)2D3 in normal man.
R H Wiesner, and
R Kumar, and
E Seeman, and
V L Go
February 1980,
The Journal of clinical investigation,
R H Wiesner, and
R Kumar, and
E Seeman, and
V L Go
August 1980,
The Journal of laboratory and clinical medicine,
R H Wiesner, and
R Kumar, and
E Seeman, and
V L Go
April 1985,
Journal of endocrinological investigation,
R H Wiesner, and
R Kumar, and
E Seeman, and
V L Go
December 1989,
Proceedings of the National Academy of Sciences of the United States of America,
R H Wiesner, and
R Kumar, and
E Seeman, and
V L Go
May 1991,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
R H Wiesner, and
R Kumar, and
E Seeman, and
V L Go
October 1979,
The Journal of endocrinology,
R H Wiesner, and
R Kumar, and
E Seeman, and
V L Go
September 1983,
The Biochemical journal,
R H Wiesner, and
R Kumar, and
E Seeman, and
V L Go
August 1982,
Biochemical and biophysical research communications,
R H Wiesner, and
R Kumar, and
E Seeman, and
V L Go
March 1974,
Science (New York, N.Y.),
R H Wiesner, and
R Kumar, and
E Seeman, and
V L Go
June 1990,
The Journal of biological chemistry,
