Biomaterial Database

Effect of dietary protein and phosphorus levels on the utilization of zinc, copper and manganese by adult males. 1980

J L Greger, and S M Snedeker

Zinc, copper and manganese utilization were examined in eight adult males fed a low protein-moderate phosphorus diet (LPrMP), a low protein-high phosphorus diet (LPrHP), a high protein-moderate phosphorus diet (HPrMP) and a high protein-high phosphorus diet (HPrHP) during a 51-day balance study. The low and high protein diets contained 8.1 g and 24.1 g nitrogen daily, respectively. The moderate and high levels of phosphorus were 1,010 and 2,525 mg phosphorus daily. Subjects lost less zinc in the feces when fed the HPrMP diet than when fed the other three diets. The level of dietary protein and phosphorus all statistically affected fecal zinc excretion. Urinary zinc excretion was significantly greater when subjects consumed the high protein diets rather than the low protein diets. Apparent retention of zinc was greatest when subjects were fed the HPrMP diet rather than the other three diets. This effect was statistically attributable to the interaction between dietary protein and phosphorus. Serum zinc levels were significantly elevated when subjects consumed the high protein rather than the low protein diets. Serum zinc levels were correlated to urinary zinc excretion (r = 0.788, P< 0.001), apparent retention of zinc (r = 0.385, P< 0.05) and serum copper levels (r = 0.395, P < 0.05). Apparent absorption and retention of copper were significantly greater when subjects were fed the high protein rather than the low protein diets. They dietary treatments did not affect the urinary excretion of copper, serum copper levels or the apparent absorption and retention of manganese by these subjects.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008345	Manganese	A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
D010758	Phosphorus	A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.	Black Phosphorus,Phosphorus-31,Red Phosphorus,White Phosphorus,Yellow Phosphorus,Phosphorus 31,Phosphorus, Black,Phosphorus, Red,Phosphorus, White,Phosphorus, Yellow
D003300	Copper	A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.	Copper-63,Copper 63
D004044	Dietary Proteins	Proteins obtained from foods. They are the main source of the ESSENTIAL AMINO ACIDS.	Proteins, Dietary,Dietary Protein,Protein, Dietary
D005243	Feces	Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D015032	Zinc	A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.