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Neoplasms of the thyroid with multinucleated, osteoclast-like giant cells, are rare. The numerous giant cells observed in these undifferentiated neoplasm have extensive eosinophilic cytoplasm and contain two to several hundred round or oval, uniform small nuclei. The clinical and morphologic data obtained from the two cases we describe and seven others collected from the literature are as follows: a) peak incidence in late adulthood; b) frequent association with a preexisting goiter (6 cases); c) rapid growth and fatal outcome within one year following diagnosis (5 cases); d) histologic pleomorphism with a background of uniform and spindle- or bizarre-shaped mononuclear cells; e) occasional coexistence of multinucleated giant cell tumor with well differentiated follicular carcinoma (1 case). Indirect evidence suggests that the multinucleated giant cells which characterize these unusual anaplastic carcinomas are epithelial in origin.
P Walter, and
J Pusel, and
P Rousselot
February 1980,
Wiener klinische Wochenschrift,
P Walter, and
J Pusel, and
P Rousselot
January 2004,
Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society,
P Walter, and
J Pusel, and
P Rousselot
October 1990,
Endocrinologia japonica,
P Walter, and
J Pusel, and
P Rousselot
June 1982,
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
P Walter, and
J Pusel, and
P Rousselot
January 1982,
Archives d'anatomie et de cytologie pathologiques,
P Walter, and
J Pusel, and
P Rousselot
August 1981,
Horumon to rinsho. Clinical endocrinology,
P Walter, and
J Pusel, and
P Rousselot
September 1991,
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc,
P Walter, and
J Pusel, and
P Rousselot
October 1981,
Nihon Gan Chiryo Gakkai shi,
P Walter, and
J Pusel, and
P Rousselot
February 1991,
Cancer,
P Walter, and
J Pusel, and
P Rousselot
October 1987,
Cancer,
