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In acute experiments on cats under urethan anaesthesia and on dogs under chloralose-urethan narcosis the effect of the cinnarizine analogue Aligeron on local cortical cerebral blood flow (local CBF) and internal carotid blood flow was studied. The local CBF was recorded by means of a thermoclearance method using thermistor transducers. In addition the cortical pH and the arterial blood pressure were registered. For determination of internal carotid flow the flowmetric method was used accompanied by a simultaneous registering of heart rate and arterial blood pressure. Cinnarizine and papaverine were used as reference compounds. The results obtained show that Aligeron increases both the internal carotid flow (with 64% in a dose of 5 mg/kg) and the local CBF (with 30% in a dose of 1 mg/kg and 40% at 5 mg/kg). This effect is higher and longer-lasting than those of cinnarizine and papaverine.
V Vlahov, and
R Nikolov, and
M Nikolova
January 1980,
Eksperimentalna meditsina i morfologiia,
V Vlahov, and
R Nikolov, and
M Nikolova
June 1968,
Proceedings of the Royal Society of Medicine,
V Vlahov, and
R Nikolov, and
M Nikolova
January 1979,
Acta physiologica et pharmacologica Bulgarica,
V Vlahov, and
R Nikolov, and
M Nikolova
September 1965,
Die Medizinische Welt,
V Vlahov, and
R Nikolov, and
M Nikolova
July 1954,
Casopis lekaru ceskych,
V Vlahov, and
R Nikolov, and
M Nikolova
December 1982,
No to shinkei = Brain and nerve,
V Vlahov, and
R Nikolov, and
M Nikolova
October 1963,
Zeitschrift fur Kreislaufforschung,
V Vlahov, and
R Nikolov, and
M Nikolova
February 1980,
No to shinkei = Brain and nerve,
V Vlahov, and
R Nikolov, and
M Nikolova
January 1981,
Methods and findings in experimental and clinical pharmacology,
V Vlahov, and
R Nikolov, and
M Nikolova
January 1964,
Zhurnal eksperimental'noi i klinicheskoi meditsiny,
