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Cystic spongioblastoma and ectopic pinealoma occurring simultaneously were found in a 16-year-old male patient, and produced destruction of the hypothalamus. The clinical course extended for over four years. The clinical picture was characterized by a defect of osmo- and thermoregulation and by defective function of diencephalic nuclei and the sympathetic nervous system. The releasing factors for ACTH, TSH, LH, and FSH were lacking and produced corresponding disturbances of pituitary function. Because of the lack of hypothalamic inhibiting factors the prolactin level was increased, and the HGH level was stimulated by arginine loading and inhibited in the glucose test. The intact neurones in the ventromedial nucleus of the hypothalamus could be seen on microscopical examination. Clinical and endrocrinological findings were more suggestive of the diagnosis than the radiological ones. Computerized tomography showed multiple "tumour" localizations without any displacement signs. The occurrence of ectopic pinealoma and spongioblastoma in the same case would suggest, from the pathological point of view, a common dysontogenetic origin developing from the local elements of the nervous tissue.
E Grote, and
R Lorenz, and
O Vuia
October 1977,
Gaceta medica de Mexico,
E Grote, and
R Lorenz, and
O Vuia
January 1974,
Klinische Monatsblatter fur Augenheilkunde,
E Grote, and
R Lorenz, and
O Vuia
September 1965,
Revista de la Sociedad Peruana de Endocrinologia,
E Grote, and
R Lorenz, and
O Vuia
April 1977,
No to shinkei = Brain and nerve,
E Grote, and
R Lorenz, and
O Vuia
February 1968,
No to shinkei = Brain and nerve,
E Grote, and
R Lorenz, and
O Vuia
January 1958,
Acta neurochirurgica,
E Grote, and
R Lorenz, and
O Vuia
January 1954,
Revista iberica de endocrinologia,
