-transparent.png){kind=logo}
Effects of pressure on cerebrospinal fluid (CSF) formation were studied in dogs with a recirculatory spinal perfusion tracer clearance technique that does not require steady-state conditions. The data permit statistical analysis of the relationship between the rate of CSF formation and pressure for individual animals. Most animals showed no statistical relationship between CSF formation and intracranial pressure (ICP) and/or cerebral perfusion pressure (CPP). In this study, a disturbance of cerebral blood flow (CBF) autoregulation may have been present in five animals on the basis of CPP reductions, and four of this latter group showed formation to decrease with increasing ICP. It is suggested that CSF formation is normally pressure insensitive. With impaired autoregulation of CBF, formation may follow CBF and CPP passively.
F H Sklar, and
J Reisch, and
I Elashvili, and
T Smith, and
D M Long
January 1974,
Laboratory animals,
F H Sklar, and
J Reisch, and
I Elashvili, and
T Smith, and
D M Long
June 1970,
Acta physiologica Scandinavica,
F H Sklar, and
J Reisch, and
I Elashvili, and
T Smith, and
D M Long
July 1971,
Experimental neurology,
F H Sklar, and
J Reisch, and
I Elashvili, and
T Smith, and
D M Long
April 1941,
Annals of surgery,
F H Sklar, and
J Reisch, and
I Elashvili, and
T Smith, and
D M Long
March 1974,
Der Nervenarzt,
F H Sklar, and
J Reisch, and
I Elashvili, and
T Smith, and
D M Long
February 1973,
British journal of anaesthesia,
F H Sklar, and
J Reisch, and
I Elashvili, and
T Smith, and
D M Long
January 1963,
Transactions - American Society for Artificial Internal Organs,
F H Sklar, and
J Reisch, and
I Elashvili, and
T Smith, and
D M Long
January 1987,
Masui. The Japanese journal of anesthesiology,
F H Sklar, and
J Reisch, and
I Elashvili, and
T Smith, and
D M Long
September 1992,
Masui. The Japanese journal of anesthesiology,
F H Sklar, and
J Reisch, and
I Elashvili, and
T Smith, and
D M Long
January 1978,
The American journal of physiology,
