[Sclerosing epithelial hamartoma: variant of trichoepithelioma. Three cases (author's transl)]. 1980

A Dupré, and J L Bonafé, and J Lassère

The sclerosing epithelial hamartoma is a variant of suborganoid hamartoma with pilar differenciation, which was set apart as a distinct entity by MacDonald, Wilson Jones and Marks in 1977. It is similar to the disease formerly described under the title "solitary trichoepithelioma". The clinical and histological features in the three cases of sclerosing epithelial hamartoma that we are reporting differed from those of multiple trichoepithelioma, from which this hamartoma must be separated nosologically. We want to emphasize the quite unusual histological appearance of our third case. The keratinizing cystic structures were quire voluminous and superficial, and there were very few epithelial strands, th histological picture thus being very misleading. We have observed a prominent associated sebaceous hyperplasia architecturally atypical which allowed this sebaceous hyperplasia to be compared to sebaceous epithelioma. Moreover, numerous cholesterol crystals were present in the keratinizing cystic structures. These crystals appeared to be breaking the epithelium of the cyst wall, which resulted in foreign body epitheloid granuloma formation. Nosologically, the sclerosing epithelial hamartoma stands between trichofolliculoma and multiple trichoepithelioma.

UI MeSH Term Description Entries
D009378 Neoplasms, Multiple Primary Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites. Neoplasms, Synchronous,Neoplasms, Synchronous Multiple Primary,Multiple Primary Neoplasms,Multiple Primary Neoplasms, Synchronous,Synchronous Multiple Primary Neoplasms,Synchronous Neoplasms,Multiple Primary Neoplasm,Neoplasm, Multiple Primary,Neoplasm, Synchronous,Primary Neoplasm, Multiple,Primary Neoplasms, Multiple,Synchronous Neoplasm
D003937 Diagnosis, Differential Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures. Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D004848 Epithelium The layers of EPITHELIAL CELLS which cover the inner and outer surfaces of the cutaneous, mucus, and serous tissues and glands of the body. Mesothelium,Epithelial Tissue,Mesothelial Tissue,Epithelial Tissues,Mesothelial Tissues,Tissue, Epithelial,Tissue, Mesothelial,Tissues, Epithelial,Tissues, Mesothelial
D005260 Female Females
D006222 Hamartoma A focal malformation resembling a neoplasm, composed of an overgrowth of mature cells and tissues that normally occur in the affected area. Hamartomas
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012598 Sclerosis A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve. Scleroses
D012878 Skin Neoplasms Tumors or cancer of the SKIN. Cancer of Skin,Skin Cancer,Cancer of the Skin,Neoplasms, Skin,Cancer, Skin,Cancers, Skin,Neoplasm, Skin,Skin Cancers,Skin Neoplasm

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