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1 It is well-known that considerable variability and unpredictability in serum concentrations results from orally administered erythromycin. 2 Disposition kinetics and their variability were studies in 24 healthy subjects after a single dose of erythromycin lactobionate and four doses were studied to evaluate dose-related variability in five other subjects. 3 Erythromycin kinetics were adequately described by a classical two compartment open model with little intersubject variability. 4 Dose-related variability occurred. Clearance was independent of dose but T1/2 beta and Vdss increased with dose. 5 Data are presented to show that non-invasive sampling of urine and saliva are of limited value in studying erythromycin pharmacokinetics.
K L Austin, and
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C R Philpot, and
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January 1988,
Therapeutic drug monitoring,
K L Austin, and
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K L Austin, and
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May 1982,
British journal of clinical pharmacology,
K L Austin, and
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K L Austin, and
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K L Austin, and
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November 1976,
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K L Austin, and
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P J McDonald
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K L Austin, and
L E Mather, and
C R Philpot, and
P J McDonald
January 2009,
European journal of internal medicine,
K L Austin, and
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Journal of veterinary pharmacology and therapeutics,
K L Austin, and
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P J McDonald
August 1953,
Antibiotics & chemotherapy (Northfield, Ill.),
