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Uptake measurements and visualization of the adrenal glands were performed using 131I-19-iodocholesterol in ten healthy subjects and fourteen patient suffering from Cushing's syndrome (nine hyperplasias and five adenomas). The normal range in healthy subjects (average uptake value +/- 2 SD) is 0.12-0.27% for both adrenals. In patients with Cushing's syndrome the uptake values ranged from 0.321 to 1.497%. Normal bilateral images were obtained in all the healthy subjects as well as in eight of the patients with hyperplasia, whilst the remaining patient with hyperplasia showed distinctly enlarged glands. In contrast, an image of the diseased side only was obtained in patients with adrenal adenomas. We conclude that radiocholesterol studies in Cushing's syndrome allow confirmation of the diagnosis, definition of the pathophysiologic type of disease and lateralization of adrenal adenomas.
D Ortega, and
M Foz, and
F M Doménech-Torné, and
J M Tresánchez
January 1976,
Annales d'endocrinologie,
D Ortega, and
M Foz, and
F M Doménech-Torné, and
J M Tresánchez
January 1976,
The Netherlands journal of medicine,
D Ortega, and
M Foz, and
F M Doménech-Torné, and
J M Tresánchez
May 1977,
The British journal of radiology,
D Ortega, and
M Foz, and
F M Doménech-Torné, and
J M Tresánchez
September 1975,
Acta endocrinologica,
D Ortega, and
M Foz, and
F M Doménech-Torné, and
J M Tresánchez
July 1976,
The Journal of clinical endocrinology and metabolism,
D Ortega, and
M Foz, and
F M Doménech-Torné, and
J M Tresánchez
January 1976,
Radiologia clinica,
D Ortega, and
M Foz, and
F M Doménech-Torné, and
J M Tresánchez
December 1976,
La Nouvelle presse medicale,
D Ortega, and
M Foz, and
F M Doménech-Torné, and
J M Tresánchez
April 1979,
Chinese medical journal,
D Ortega, and
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F M Doménech-Torné, and
J M Tresánchez
May 1975,
Acta medica Scandinavica,
D Ortega, and
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F M Doménech-Torné, and
J M Tresánchez
January 1976,
New York state journal of medicine,
