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Acipimox (5-methylpyrazinecarboxylic acid 4-oxide) is a new lipolysis inhibitor that has a distant chemical relationship with nicotinic acid (NA). The tritiated compound (100 mg) is rapidly absorbed, peak plasma radioactivity being reached after 2 hr, with an almost total elimination unchanged in urine. A comparison of th antilipolytic activity of three doses of acipimox and three doses of NA showed acipimox to be 20 times as potent as NA. There was a correlation between intensity and duration of effect for acipimox, but not for NA. Plasma acipimox levels correlated with inhibition of lipolysis. In consideration of the very good subjective tolerability of acipimox at all doses tested, this drug may be suitable for control of lipolysis in hyperlipidemias.
L M Fuccella, and
G Goldaniga, and
P Lovisolo, and
E Maggi, and
L Musatti, and
V Mandelli, and
C R Sirtori
June 1993,
Annals of the New York Academy of Sciences,
L M Fuccella, and
G Goldaniga, and
P Lovisolo, and
E Maggi, and
L Musatti, and
V Mandelli, and
C R Sirtori
August 1979,
European journal of clinical pharmacology,
L M Fuccella, and
G Goldaniga, and
P Lovisolo, and
E Maggi, and
L Musatti, and
V Mandelli, and
C R Sirtori
January 1966,
Naunyn-Schmiedebergs Archiv fur Pharmakologie und experimentelle Pathologie,
L M Fuccella, and
G Goldaniga, and
P Lovisolo, and
E Maggi, and
L Musatti, and
V Mandelli, and
C R Sirtori
July 1991,
Drug and therapeutics bulletin,
L M Fuccella, and
G Goldaniga, and
P Lovisolo, and
E Maggi, and
L Musatti, and
V Mandelli, and
C R Sirtori
January 1973,
Atherosclerosis,
L M Fuccella, and
G Goldaniga, and
P Lovisolo, and
E Maggi, and
L Musatti, and
V Mandelli, and
C R Sirtori
January 1985,
Clinical science (London, England : 1979),
L M Fuccella, and
G Goldaniga, and
P Lovisolo, and
E Maggi, and
L Musatti, and
V Mandelli, and
C R Sirtori
April 1992,
British journal of clinical pharmacology,
L M Fuccella, and
G Goldaniga, and
P Lovisolo, and
E Maggi, and
L Musatti, and
V Mandelli, and
C R Sirtori
January 1983,
Arzneimittel-Forschung,
L M Fuccella, and
G Goldaniga, and
P Lovisolo, and
E Maggi, and
L Musatti, and
V Mandelli, and
C R Sirtori
January 1978,
Advances in experimental medicine and biology,
L M Fuccella, and
G Goldaniga, and
P Lovisolo, and
E Maggi, and
L Musatti, and
V Mandelli, and
C R Sirtori
February 2020,
Shock (Augusta, Ga.),
