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Gastric lesions were produced in rats by the administration for 2 weeks of 300 mg/kg/day of mepirizole, a basic non-steroidal antiinflammatory compound. Although the single administration of 200 mg/kg of mepirizole had no effect, the addition of water-immersion stress for one hour induced lesions not only in the corpus but also in the pyloric antrum. The administration of 250 mg/kg of mefenamic acid, an acidic non-steroidal antiinflammatory compound (insufficient for producing gastric lesions at this dose alone) with the addition of one hour of water-immersion stress induced gastric lesions. The addition of 200 mg/kg of mepirizole reduced the ulcer index from 8.1 to 4.7 in the corpus and from 4 to 0.5 in the pyloric antrum. It is suggested that basic antiinflammatory compounds inhibit gastric lesions induced by combination of acidic antiinflammatory compounds and water-immersion stress.
K Kobayashi, and
S Chono, and
H Yamada
January 1983,
Acta physiologica Polonica,
K Kobayashi, and
S Chono, and
H Yamada
January 1997,
Klinicheskaia meditsina,
K Kobayashi, and
S Chono, and
H Yamada
January 2000,
Klinicheskaia meditsina,
K Kobayashi, and
S Chono, and
H Yamada
January 2008,
Klinicheskaia meditsina,
K Kobayashi, and
S Chono, and
H Yamada
August 1986,
Japanese journal of pharmacology,
K Kobayashi, and
S Chono, and
H Yamada
January 1979,
Arzneimittel-Forschung,
K Kobayashi, and
S Chono, and
H Yamada
May 1988,
Indian journal of experimental biology,
K Kobayashi, and
S Chono, and
H Yamada
February 1989,
Digestive diseases and sciences,
K Kobayashi, and
S Chono, and
H Yamada
October 1968,
Nihon ganka kiyo,
K Kobayashi, and
S Chono, and
H Yamada
March 1989,
Chemical & pharmaceutical bulletin,
