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Pregnant female rats were hypophysectomized on the 14th day of pregnancy without fetal loss or premature delivery. Completeness of hypophysectomy was confirmed by measurements of serum growth hormone and prolactin. Serum somatomedin activities were measured by the hypophysectomized rat costal cartilage in vitro assay using a human serum standard. In this assay somatomedin activity of normal rat serum is about four times that of normal human serum. Forty-eight hours after hypophysectomy serum somatomedin was maintained at 3.9 +/- 1.0 units/ml. At this time after operation somatomedin activity of nonpregnant hypophysectomized rat serum would be virtually undetectable. Somatomedin concentrations were still maintained on the 18th and 20th day of pregnancy. However, within 24 hours after delivery somatomedin had fallen to less than 0.6 units/ml and by three days post delivery were less than 0.2 units/ml. These observations indicate that the fetal-placental unit, probably by secreting a chorionic somatomammotropin, can maintain the concentration of growth hormone-dependent somatomedin in tha absence of the pituitary.
W H Daughaday, and
M Kapadia
February 1978,
Endocrinology,
W H Daughaday, and
M Kapadia
December 1978,
Canadian journal of physiology and pharmacology,
W H Daughaday, and
M Kapadia
November 1979,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
W H Daughaday, and
M Kapadia
June 1976,
Diabetes,
W H Daughaday, and
M Kapadia
January 1975,
Advances in metabolic disorders,
W H Daughaday, and
M Kapadia
January 1973,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
W H Daughaday, and
M Kapadia
July 1976,
Endocrinology,
W H Daughaday, and
M Kapadia
December 1973,
European journal of pharmacology,
W H Daughaday, and
M Kapadia
October 1972,
Acta endocrinologica,
W H Daughaday, and
M Kapadia
May 1966,
Experientia,
