Biomaterial Database

Objectionable urine spraying and urine marking in cats: evaluation of progestin treatment in gonadectomized males and females. 1980

B L Hart

The increasing use of long-acting progestins to treat objectionable urine spraying and urine marking in gonadectomized cats prompted a survey of the comparative effectiveness of the injectable medroxyprogesterone acetate (MPA) and the orally administered megestrol acetate (MA). Both drugs were successful, overall, in about 1/3 of the patients. However, the proportion with favorable response was higher for males (48%) than for females (13%) and was higher for cats from single-cat homes (50%) than for cats from multi-cat homes (18%). Because of the reportedly higher frequency of depression and increased appetite following MA treatment, when compared with MPA treatment, it is recommended that MPA be used initially for routine treatment of these behavioral problems. The survey revealed that if MPA proves ineffective, subsequent treatment with MA can be expected to yield favorable results in some of these patients.

UI	MeSH Term	Description	Entries
D007273	Injections, Intramuscular	Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.	Intramuscular Injections,Injection, Intramuscular,Intramuscular Injection
D008297	Male		Males
D008525	Medroxyprogesterone	A synthetic progestational hormone used in veterinary practice as an estrus regulator.	(6 alpha)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione,Methylhydroxyprogesterone,Pregn-4-ene-3,20-dione, 17-hydroxy-6-methyl-, (6alpha)-,17 alpha-Hydroxy-6 alpha-Methylprogesterone,Adgyn Medro,17 alpha Hydroxy 6 alpha Methylprogesterone
D008535	Megestrol	A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.	17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione,Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-
D002369	Castration	Surgical removal or artificial destruction of gonads.	Gonadectomy,Castrations,Gonadectomies
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D004609	Eliminative Behavior, Animal	Behavior associated with the elimination of feces and urine from the body.	Eliminative Behavior,Animal Eliminative Behavior,Animal Eliminative Behaviors,Behavior, Animal Eliminative,Behavior, Eliminative,Behaviors, Animal Eliminative,Behaviors, Eliminative,Eliminative Behaviors,Eliminative Behaviors, Animal
D005260	Female		Females
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia