BIOMAT Database Logo BIOMAT Database Logo

MAO, DBH and COMT: the effect of anxiety. 1980

R J Mathew, and B T Ho, and P Kralik, and D Taylor, and J L Claghorn

Anxiety, a common accompaniment of depression, can be a source of confusion in affective disorder research. The present study examined the effect of anxiety on platelet monoamine oxidase, RBC catechol-0-methyltransferase, and serum dopamine-beta-hydroxylase-enzymes frequently implicated in affective disorders. Levels of anxiety, plasma catecholamines and the enzymes mentioned above were quantified in groups of anxious subjects and mentally and physically healthy controls. Anxious subjects were found to have significantly higher levels of blood plasma catecholamines and platelet monoamine oxidase. significant positive correlations were demonstrated between plasma catecholamines and platelet monoamine oxidase, while significant inverse correlations were found between trait anxiety and COMT, norepinephrine and DBH, and COMT and DBH

UI MeSH Term Description Entries
D008297 Male Males
D008995 Monoamine Oxidase An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4. Amine Oxidase (Flavin-Containing),MAO,MAO-A,MAO-B,Monoamine Oxidase A,Monoamine Oxidase B,Type A Monoamine Oxidase,Type B Monoamine Oxidase,Tyramine Oxidase,MAO A,MAO B,Oxidase, Monoamine,Oxidase, Tyramine
D009638 Norepinephrine Precursor of epinephrine that is secreted by the ADRENAL MEDULLA and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers, and of the diffuse projection system in the brain that arises from the LOCUS CERULEUS. It is also found in plants and is used pharmacologically as a sympathomimetic. Levarterenol,Levonorepinephrine,Noradrenaline,Arterenol,Levonor,Levophed,Levophed Bitartrate,Noradrenaline Bitartrate,Noradrénaline tartrate renaudin,Norepinephrin d-Tartrate (1:1),Norepinephrine Bitartrate,Norepinephrine Hydrochloride,Norepinephrine Hydrochloride, (+)-Isomer,Norepinephrine Hydrochloride, (+,-)-Isomer,Norepinephrine d-Tartrate (1:1),Norepinephrine l-Tartrate (1:1),Norepinephrine l-Tartrate (1:1), (+,-)-Isomer,Norepinephrine l-Tartrate (1:1), Monohydrate,Norepinephrine l-Tartrate (1:1), Monohydrate, (+)-Isomer,Norepinephrine l-Tartrate (1:2),Norepinephrine l-Tartrate, (+)-Isomer,Norepinephrine, (+)-Isomer,Norepinephrine, (+,-)-Isomer
D002394 Catechol O-Methyltransferase Enzyme that catalyzes the movement of a methyl group from S-adenosylmethionone to a catechol or a catecholamine. Catechol Methyltransferase,Catechol-O-Methyltransferase,Catechol O Methyltransferase,Methyltransferase, Catechol,O-Methyltransferase, Catechol
D004299 Dopamine beta-Hydroxylase Dopamine beta-Monooxygenase,Dopamine beta Hydroxylase,Dopamine beta Monooxygenase,beta-Hydroxylase, Dopamine,beta-Monooxygenase, Dopamine
D004837 Epinephrine The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS. Adrenaline,4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol,Adrenaline Acid Tartrate,Adrenaline Bitartrate,Adrenaline Hydrochloride,Epifrin,Epinephrine Acetate,Epinephrine Bitartrate,Epinephrine Hydrochloride,Epinephrine Hydrogen Tartrate,Epitrate,Lyophrin,Medihaler-Epi,Acetate, Epinephrine
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D001008 Anxiety Disorders Persistent and disabling ANXIETY. Anxiety Neuroses,Anxiety States, Neurotic,Neuroses, Anxiety,Anxiety Disorder,Anxiety State, Neurotic,Disorder, Anxiety,Disorders, Anxiety,Neurotic Anxiety State,Neurotic Anxiety States,State, Neurotic Anxiety,States, Neurotic Anxiety

Related Publications

R J Mathew, and B T Ho, and P Kralik, and D Taylor, and J L Claghorn
Longitudinal assessment of MAO-, COMT-, and DBH- activity in patients with bipolar depression.
January 1982, International pharmacopsychiatry,
R J Mathew, and B T Ho, and P Kralik, and D Taylor, and J L Claghorn
A twin study on three enzymes (DBH, COMT, MAO) of catecholamine metabolism. Correlations with MMPI.
April 1978, Psychopharmacology,
R J Mathew, and B T Ho, and P Kralik, and D Taylor, and J L Claghorn
Association Between Polymorphisms of DRD2, COMT, DBH, and MAO-A Genes and Migraine Susceptibility: A Meta-Analysis.
November 2015, Medicine,
R J Mathew, and B T Ho, and P Kralik, and D Taylor, and J L Claghorn
Segregation and linkage studies of plasma dopamine-beta-hydroxylase (DBH), erythrocyte catechol-O-methyltransferase (COMT), and platelet monoamine oxidase (MAO): possible linkage between the ABO locus and a gene controlling DBH activity.
March 1982, American journal of human genetics,
R J Mathew, and B T Ho, and P Kralik, and D Taylor, and J L Claghorn
Studies on biogenic amine metabolizing enzymes (DBH, COMT, MAO) and pathogenesis of affective illness. III. Platelet monoamine oxidase activity in endogenous depression.
February 1983, Acta psychiatrica Scandinavica,
R J Mathew, and B T Ho, and P Kralik, and D Taylor, and J L Claghorn
DBH, MHPG, and MAO in children with depressive, anxiety, and conduct disorders: relationship to diagnosis and symptom ratings.
April 1988, Psychiatry research,
R J Mathew, and B T Ho, and P Kralik, and D Taylor, and J L Claghorn
Modifier effects in autism at the MAO-A and DBH loci.
April 2004, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics,
R J Mathew, and B T Ho, and P Kralik, and D Taylor, and J L Claghorn
Studies on biogenic amine metabolizing enzymes (DBH, COMT, MAO) and pathogenesis of affective illness. I. Plasma dopamine-beta-hydroxylase activity in endogenous depression.
February 1983, Acta psychiatrica Scandinavica,
R J Mathew, and B T Ho, and P Kralik, and D Taylor, and J L Claghorn
Studies on biogenic amine metabolizing enzymes (DBH, COMT, MAO) and pathogenesis of affective illness. II. Erythrocyte catechol-O-methyltransferase activity in endogenous depression.
February 1983, Acta psychiatrica Scandinavica,
R J Mathew, and B T Ho, and P Kralik, and D Taylor, and J L Claghorn
Serum DBH and platelet MAO in patients with depressive disorders.
January 1981, Pharmacopsychiatria,
Copied contents to your clipboard!