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A comparison of the receptor binding properties and in vitro metabolism of angiotensin II and [des-Asp1]-angiotensin II was performed in collagenase-dispersed glomerulosa cells from dog adrenal glands. Each peptide was bound rapidly and reversibly to isolated glomerulosa cells, with similar equilibrium and kinetic constants of association and dissociation. The labeled peptide that was bound to glomerulosa cells after incubation with 125I- and 3H-angiotensin II at 37C for 30-60 minutes was predominantly angiotensin II, with about 15% [des-Asp1]-angiotensin II. These findings demonstrate that local formation of the heptapeptide is not an obligatory step in the action of angiotensin II on aldosterone production in the canine adrenals.
J Douglas, and
P Bartley, and
T Kondo, and
K Catt
November 1994,
Biological & pharmaceutical bulletin,
J Douglas, and
P Bartley, and
T Kondo, and
K Catt
September 1977,
Endocrinology,
J Douglas, and
P Bartley, and
T Kondo, and
K Catt
February 1978,
Clinical science and molecular medicine,
J Douglas, and
P Bartley, and
T Kondo, and
K Catt
January 1982,
Clinical and experimental pharmacology & physiology. Supplement,
J Douglas, and
P Bartley, and
T Kondo, and
K Catt
February 1978,
Acta endocrinologica,
J Douglas, and
P Bartley, and
T Kondo, and
K Catt
March 1979,
The American journal of physiology,
J Douglas, and
P Bartley, and
T Kondo, and
K Catt
December 1975,
Journal of medicinal chemistry,
J Douglas, and
P Bartley, and
T Kondo, and
K Catt
April 1977,
Federation proceedings,
J Douglas, and
P Bartley, and
T Kondo, and
K Catt
May 1979,
Endocrinology,
J Douglas, and
P Bartley, and
T Kondo, and
K Catt
April 1982,
Acta endocrinologica,
