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Magnesium infusions were carried out in normal subjects and patients with hypoparathyroidism and primary hyperparathyroidism in order to determine if a tubular maximum for magnesium (TmMg) existed in man and what influence endogenous parathyroid hormone played in renal magnesium handling. The increase in the serum ultrafiltrable magnesium concentration during the magnesium infusions resulted in an increase in urinary magnesium excretion. A TmMg of 1.4 mg/100 ml GF/1.73 m2 was found in the normal subjects under basal conditions. Similarly, TmMg values of 1.4 and 1.3 mg/100 ml GF/1.73 m2, were found in hypoparathyroid and primary hyperparathyroid subjects, respectively. Both were present under basal conditions and neither differed significantly from normal. It is concluded that a TmMg is present in man and that endogenous parathyroid hormone does not appear to play a significant physiological role in renal magnesium homeostasis.
R K Rude, and
J E Bethune, and
F R Singer
December 2000,
The New England journal of medicine,
R K Rude, and
J E Bethune, and
F R Singer
March 2001,
The New England journal of medicine,
R K Rude, and
J E Bethune, and
F R Singer
January 2001,
The New England journal of medicine,
R K Rude, and
J E Bethune, and
F R Singer
June 1988,
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R K Rude, and
J E Bethune, and
F R Singer
January 1953,
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R K Rude, and
J E Bethune, and
F R Singer
May 1954,
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R K Rude, and
J E Bethune, and
F R Singer
June 1963,
Klinische Wochenschrift,
R K Rude, and
J E Bethune, and
F R Singer
March 1971,
Israel journal of medical sciences,
R K Rude, and
J E Bethune, and
F R Singer
March 1941,
The Journal of clinical investigation,
R K Rude, and
J E Bethune, and
F R Singer
October 1966,
Metabolism: clinical and experimental,
