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Further in vitro studies of hematopoietic regulation were carried out in two patients with polycythemia vera who were also heterozygotes (Gd(B)/Gd(A)) for glucose-6-phosphate-dehydrogenase (G-6-PD). While only G-6-PD type A was detectable in circulating erythrocytes, granulocytes and platelets, cultures of peripheral blood and marrow from one patient revealed a substantial number of G-6-PD type B erythroid burst-forming units (BFU-E) and granulocyte/macrophage colony-forming units. Detailed analysis demonstrated: (a) where detectable, normal BFU-E and granulocyte/macrophage colony-forming units were found with similar frequencies; (b) the same frequencies for normal progenitors characterized cultures of peripheral blood and marrow; (c) inhibition of normal erythroid differentiation between BFU-E and the more mature erythroid colony-forming unit; (d) a decline in the prevalence of normal colony-forming units with time, suggesting that disease progression is associated with further suppression of normal hematopoiesis by products of the abnormal clone.
J W Adamson, and
J W Singer, and
P Catalano, and
S Murphy, and
N Lin, and
L Steinmann, and
C Ernst, and
P J Fialkow
January 1976,
Seminars in hematology,
J W Adamson, and
J W Singer, and
P Catalano, and
S Murphy, and
N Lin, and
L Steinmann, and
C Ernst, and
P J Fialkow
December 1992,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
J W Adamson, and
J W Singer, and
P Catalano, and
S Murphy, and
N Lin, and
L Steinmann, and
C Ernst, and
P J Fialkow
May 1982,
The Journal of clinical investigation,
J W Adamson, and
J W Singer, and
P Catalano, and
S Murphy, and
N Lin, and
L Steinmann, and
C Ernst, and
P J Fialkow
December 1969,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
J W Adamson, and
J W Singer, and
P Catalano, and
S Murphy, and
N Lin, and
L Steinmann, and
C Ernst, and
P J Fialkow
January 1976,
Seminars in hematology,
J W Adamson, and
J W Singer, and
P Catalano, and
S Murphy, and
N Lin, and
L Steinmann, and
C Ernst, and
P J Fialkow
November 1978,
Virchows Archiv. B, Cell pathology,
J W Adamson, and
J W Singer, and
P Catalano, and
S Murphy, and
N Lin, and
L Steinmann, and
C Ernst, and
P J Fialkow
January 1988,
Neoplasma,
J W Adamson, and
J W Singer, and
P Catalano, and
S Murphy, and
N Lin, and
L Steinmann, and
C Ernst, and
P J Fialkow
July 1948,
The Journal of clinical investigation,
J W Adamson, and
J W Singer, and
P Catalano, and
S Murphy, and
N Lin, and
L Steinmann, and
C Ernst, and
P J Fialkow
July 1984,
Cancer genetics and cytogenetics,
J W Adamson, and
J W Singer, and
P Catalano, and
S Murphy, and
N Lin, and
L Steinmann, and
C Ernst, and
P J Fialkow
March 1969,
Orvosi hetilap,
