BIOMAT Database Logo BIOMAT Database Logo

[Effect of 2-(5-methyl-4-imidazolyl)-1-methylethylamine on histamine receptors]. 1978

M Impicciatore, and G Bertaccini, and M Chiavarini, and E Molina, and T Vitali, and F Bordi

Compound 2-(5-methyl-4-imidazolyl)-1-methylethylamine was tested on different preparations for its histamine-like activity. It was found to markedly affect H2 receptors and at the same time to be practically devoid of any activity on H1 receptors. This high selectivity of action indicates that this compound may represent a useful tool for characterizing the distribution of H2 and H1 receptor sites.

UI MeSH Term Description Entries
D007082 Ileum The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
D007093 Imidazoles Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
D009119 Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments. Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D009130 Muscle, Smooth Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed) Muscle, Involuntary,Smooth Muscle,Involuntary Muscle,Involuntary Muscles,Muscles, Involuntary,Muscles, Smooth,Smooth Muscles
D011968 Receptors, Histamine Cell-surface proteins that bind histamine and trigger intracellular changes influencing the behavior of cells. Histamine receptors are widespread in the central nervous system and in peripheral tissues. Three types have been recognized and designated H1, H2, and H3. They differ in pharmacology, distribution, and mode of action. Histamine Binding Sites,Histamine Receptors,Histamine Receptor,Binding Sites, Histamine,Receptor, Histamine,Sites, Histamine Binding
D011969 Receptors, Histamine H1 A class of histamine receptors discriminated by their pharmacology and mode of action. Most histamine H1 receptors operate through the inositol phosphate/diacylglycerol second messenger system. Among the many responses mediated by these receptors are smooth muscle contraction, increased vascular permeability, hormone release, and cerebral glyconeogenesis. (From Biochem Soc Trans 1992 Feb;20(1):122-5) H1 Receptor,Histamine H1 Receptors,H1 Receptors,Histamine H1 Receptor,Receptors, H1,H1 Receptor, Histamine,H1 Receptors, Histamine,Receptor, H1,Receptor, Histamine H1
D011970 Receptors, Histamine H2 A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H2 receptors act via G-proteins to stimulate ADENYLYL CYCLASES. Among the many responses mediated by these receptors are gastric acid secretion, smooth muscle relaxation, inotropic and chronotropic effects on heart muscle, and inhibition of lymphocyte function. (From Biochem Soc Trans 1992 Feb;20(1):122-5) Histamine H2 Receptors,H2 Receptors,Receptors, H2,H2 Receptors, Histamine
D002415 Cats The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801) Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D005260 Female Females
D005704 Gallbladder A storage reservoir for BILE secretion. Gallbladder allows the delivery of bile acids at a high concentration and in a controlled manner, via the CYSTIC DUCT to the DUODENUM, for degradation of dietary lipid. Gallbladders

Related Publications

M Impicciatore, and G Bertaccini, and M Chiavarini, and E Molina, and T Vitali, and F Bordi
Effect of 6-(1'-methyl-4'-nitro-5'-imidazolyl)-mercaptopurine and 2-amino-6-(1'-methyl-4'-nitro-5'-imidazolyl)-mercaptopurine on the rat litter in utero.
December 1962, Journal of reproduction and fertility,
M Impicciatore, and G Bertaccini, and M Chiavarini, and E Molina, and T Vitali, and F Bordi
[Effect of 2-(5-methyl-4-imidazolyl)ethylamine (5-methylhistamine) on gastric secretion in humans].
May 1974, Bollettino della Societa italiana di biologia sperimentale,
M Impicciatore, and G Bertaccini, and M Chiavarini, and E Molina, and T Vitali, and F Bordi
2-Amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3, 4-thiadiazole: a new antimicrobial agent.
December 1968, Science (New York, N.Y.),
M Impicciatore, and G Bertaccini, and M Chiavarini, and E Molina, and T Vitali, and F Bordi
Nitroheterocyclic antimicrobial agents. 1-Methyl-2-nitro-5-imidazolyl derivatives.
October 1972, Journal of medicinal chemistry,
M Impicciatore, and G Bertaccini, and M Chiavarini, and E Molina, and T Vitali, and F Bordi
Effect of 2-amino-6-[(1-methyl-4-nitro-5-imidazolyl)thio]purine (imidazolylthioguanine; B.W. 57-323) on acute leukemia in man.
July 1960, Cancer chemotherapy reports,
M Impicciatore, and G Bertaccini, and M Chiavarini, and E Molina, and T Vitali, and F Bordi
Preparation, antimicrobial evaluation, and mutagenicity of [2-hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl]methanols , [5-tert-butyl-2-methylaminophenyl]-[1-methyl-5-nitro-1H-2-imidazo lyl]me thanol, and [2-hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl] ketones.
October 1997, Bioorganic & medicinal chemistry,
M Impicciatore, and G Bertaccini, and M Chiavarini, and E Molina, and T Vitali, and F Bordi
Proceedings: 3-(4(5)-imidazolyl) propylguanidine (SK&F 91486) - a partial agonist at histamine H2-receptors.
December 1975, Agents and actions,
M Impicciatore, and G Bertaccini, and M Chiavarini, and E Molina, and T Vitali, and F Bordi
The effectiveness of 2-amino-6-[(1-methyl-4-nitro-5-imidazolyl)thio] purine against transplantable mouse leukemia.
July 1960, Cancer chemotherapy reports,
M Impicciatore, and G Bertaccini, and M Chiavarini, and E Molina, and T Vitali, and F Bordi
Synthesis and calcium channel antagonist activity of nifedipine analogues containing 4(5)-chloro-2-methyl-5(4)-imidazolyl substituent.
January 2001, Bollettino chimico farmaceutico,
M Impicciatore, and G Bertaccini, and M Chiavarini, and E Molina, and T Vitali, and F Bordi
The metabolism of 2-amino-6-[(1-methyl-4-nitro-5-imidazolyl)thio]purine (B.W. 57-323) in man.
July 1960, Cancer chemotherapy reports,
Copied contents to your clipboard!