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Monocyte mediated lysis of human type B-erythrocytes coated with heat-inactivated anti-B serum was measured as 51Cr-release. Preincubation of monocytes with heat-inactivated normal AB serum inhibited cytolysis while a strong stimulation of cytolysis was seen with fresh AB serum. These effects of serum were reversible upon cell washing. Preincubation of monocytes with hyperimmune human serum against type B erythrocytes did not alter the cytolysis. After incubation at 37 degrees C of monocytes with immune complexes formed of human albumin and rabbit anti-human albumin a dose-related inhibition of cytolysis was observed. This inhibition was equally expressed at different albumin to anti-albumin ratios. Pretreatment with immune complexes at 4 degrees C had the same effect on cytolysis as pretreatment at 37 degrees C. The effect of immune complexes on monocyte-mediated cytolysis was resistant to repeated cell washing. After incubation of pretreated monocytes at 37 degrees C for up to 18 h some of the inhibition disappeared, but without normalization. Platelet depletion of monocyte suspensions resulted in a significant increase of cytolysis, and addition of washed platelets reinduced a decreased of cytolysis, which correlated with the number of platelets added.
K Kragballe, and
J Ellegaard, and
T Herlin
July 1987,
Immunology letters,
K Kragballe, and
J Ellegaard, and
T Herlin
June 1982,
Clinical and experimental immunology,
K Kragballe, and
J Ellegaard, and
T Herlin
July 1981,
The British journal of dermatology,
K Kragballe, and
J Ellegaard, and
T Herlin
December 1988,
Clinical and experimental immunology,
K Kragballe, and
J Ellegaard, and
T Herlin
February 1988,
Immunology letters,
K Kragballe, and
J Ellegaard, and
T Herlin
June 1983,
Journal of the Reticuloendothelial Society,
K Kragballe, and
J Ellegaard, and
T Herlin
February 1979,
Allergy,
K Kragballe, and
J Ellegaard, and
T Herlin
September 1980,
The Journal of clinical endocrinology and metabolism,
K Kragballe, and
J Ellegaard, and
T Herlin
November 1974,
Journal of immunology (Baltimore, Md. : 1950),
K Kragballe, and
J Ellegaard, and
T Herlin
December 1976,
Blood,
